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MedKoo Cat#: 573472 | Name: AGN-2979

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AGN-2979 is a tryptophan hydroxylase (TPH) activation inhibitor that shows antidepressant properties in rodent models of depression.

Chemical Structure

AGN-2979
AGN-2979
CAS#53873-21-5

Theoretical Analysis

MedKoo Cat#: 573472

Name: AGN-2979

CAS#: 53873-21-5

Chemical Formula: C19H28N2O3

Exact Mass: 332.2100

Molecular Weight: 332.44

Elemental Analysis: C, 68.65; H, 8.49; N, 8.43; O, 14.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AGN-2979, AGN2979, AGN 2979, SC 48274
IUPAC/Chemical Name
2,6-Piperidinedione, 3-(3-(dimethylamino)propyl)-3-(3-methoxyphenyl)-4,4-dimethyl-
InChi Key
UJFNSGBGJMRZKS-UHFFFAOYSA-N
InChi Code
1S/C19H28N2O3/c1-18(2)13-16(22)20-17(23)19(18,10-7-11-21(3)4)14-8-6-9-15(12-14)24-5/h6,8-9,12H,7,10-11,13H2,1-5H3,(H,20,22,23)
SMILES Code
N1C([C@@](C(CC1=O)(C)C)(c1cc(ccc1)OC)CCCN(C)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 332.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kanemaru K, Nishi K, Diksic M. AGN-2979, an inhibitor of tryptophan hydroxylase activation, does not affect serotonin synthesis in Flinders Sensitive Line rats, a rat model of depression, but produces a significant effect in Flinders Resistant Line rats. Neurochem Int. 2009 Dec;55(7):529-35. doi: 10.1016/j.neuint.2009.05.008. Epub 2009 May 20. PubMed PMID: 19463878; PubMed Central PMCID: PMC2778282. 2: Hasegawa S, Kanemaru K, Gittos M, Diksic M. The tryptophan hydroxylase activation inhibitor, AGN-2979, decreases regional 5-HT synthesis in the rat brain measured with alpha-[14C]methyl-L-tryptophan: an autoradiographic study. Brain Res Bull. 2005 Oct 15;67(3):248-55. PubMed PMID: 16144662.