MedKoo Cat#: 573443 | Name: Otenzepad, (+)-

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Otenzepad, (+)- is a muscarinic receptor antagonist.

Chemical Structure

Otenzepad, (+)-
Otenzepad, (+)-
CAS#121029-35-4

Theoretical Analysis

MedKoo Cat#: 573443

Name: Otenzepad, (+)-

CAS#: 121029-35-4

Chemical Formula: C24H31N5O2

Exact Mass: 421.2478

Molecular Weight: 421.55

Elemental Analysis: C, 68.38; H, 7.41; N, 16.61; O, 7.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AF-DX-250, AFDX-250, Otenzepad, (+)-
IUPAC/Chemical Name
6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 11-(2-(2-((diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro-, (+)-
InChi Key
UBRKDAVQCKZSPO-UHFFFAOYSA-N
InChi Code
1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)
SMILES Code
CCN(CC)CC1CCCCN1CC(=O)N2c3ccccc3C(=O)Nc4cccnc24
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 421.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Leaderbrand K, Chen HJ, Corcoran KA, Guedea AL, Jovasevic V, Wess J, Radulovic J. Muscarinic acetylcholine receptors act in synergy to facilitate learning and memory. Learn Mem. 2016 Oct 17;23(11):631-638. doi: 10.1101/lm.043133.116. Print 2016 Nov. PubMed PMID: 27918283; PubMed Central PMCID: PMC5066603. 2: Lanzafame A, Christopoulos A, Mitchelson F. The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea pig atria. Eur J Pharmacol. 2001 Mar 30;416(3):235-44. Erratum in: Eur J Pharmacol 2001 Jun 29;423(1):93-4. PubMed PMID: 11290374. 3: Bellido I, Fernández JL, Gómez A, Sánchez de la Cuesta F. Otenzepad shows two populations of binding sites in human gastric smooth muscle. Can J Physiol Pharmacol. 1995 Jan;73(1):124-9. PubMed PMID: 7600442.