GSNO | CAS#57564-91-7 | transnitrosation donor

MedKoo Cat#: 562500 | Name: GSNO

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. It acts by regulating diverse protein functions

Chemical Structure

GSNO

CAS#57564-91-7

Theoretical Analysis

MedKoo Cat#: 562500

Name: GSNO

CAS#: 57564-91-7

Chemical Formula: C10H16N4O7S

Exact Mass: 336.0740

Molecular Weight: 336.31

Elemental Analysis: C, 35.71; H, 4.80; N, 16.66; O, 33.30; S, 9.53

Price and Availability

Size	Price	Availability
100mg	USD 250.00	2 Weeks
250mg	USD 450.00	2 Weeks
500mg	USD 650.00	2 Weeks
1g	USD 950.00	2 Weeks

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Related CAS #

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Synonym

GSNO; SNOG; SNO-G; S-Nitrosoglutathione; Glutathione thionitrite; Nitrosoglutathione; H-gGlu-Cys(NO)-Gly-OH; S-Nitroso-L-glutathione

IUPAC/Chemical Name

N5-((R)-1-((carboxymethyl)amino)-3-(nitrosothio)-1-oxopropan-2-yl)-L-glutamine

InChi Key

HYHSBSXUHZOYLX-WDSKDSINSA-N

InChi Code

InChI=1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/m0/s1

SMILES Code

OC(CNC([C@@H](NC(CC[C@H](N)C(O)=O)=O)CSN=O)=O)=O

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 336.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Neural Regen Res. 2017 May;12(5):696-701. doi: 10.4103/1673-5374.206632. Review. PubMed PMID: 28616019; PubMed Central PMCID: PMC5461600. 4: Barnett SD, Buxton ILO. The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy. Crit Rev Biochem Mol Biol. 2017 Jun;52(3):340-354. doi: 10.1080/10409238.2017.1304353. Epub 2017 Apr 10. Review. PubMed PMID: 28393572; PubMed Central PMCID: PMC5597050. 5: Everett TR, Wilkinson IB, Lees CC. Pre-eclampsia: the Potential of GSNO Reductase Inhibitors. Curr Hypertens Rep. 2017 Mar;19(3):20. doi: 10.1007/s11906-017-0717-2. Review. PubMed PMID: 28271419; PubMed Central PMCID: PMC5340829. 6: Farnese FS, Menezes-Silva PE, Gusman GS, Oliveira JA. When Bad Guys Become Good Ones: The Key Role of Reactive Oxygen Species and Nitric Oxide in the Plant Responses to Abiotic Stress. Front Plant Sci. 2016 Apr 12;7:471. doi: 10.3389/fpls.2016.00471. eCollection 2016. Review. 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Curr Opin Pharmacol. 2014 Dec;19:54-60. doi: 10.1016/j.coph.2014.07.009. Epub 2014 Aug 7. Review. PubMed PMID: 25108170; PubMed Central PMCID: PMC4254210. 11: Pelgrift RY, Friedman AJ. Nanotechnology as a therapeutic tool to combat microbial resistance. Adv Drug Deliv Rev. 2013 Nov;65(13-14):1803-15. doi: 10.1016/j.addr.2013.07.011. Epub 2013 Jul 24. Review. PubMed PMID: 23892192. 12: Martinez M, Weisel JW, Ischiropoulos H. Functional impact of oxidative posttranslational modifications on fibrinogen and fibrin clots. Free Radic Biol Med. 2013 Dec;65:411-8. doi: 10.1016/j.freeradbiomed.2013.06.039. Epub 2013 Jul 11. Review. PubMed PMID: 23851017; PubMed Central PMCID: PMC3852169. 13: Lu C, Kavalier A, Lukyanov E, Gross SS. S-sulfhydration/desulfhydration and S-nitrosylation/denitrosylation: a common paradigm for gasotransmitter signaling by H2S and NO. Methods. 2013 Aug 1;62(2):177-81. doi: 10.1016/j.ymeth.2013.05.020. Epub 2013 Jun 27. Review. 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