JTS-653 | CAS# 942614-99-5 | TRPV1 Antagonist

MedKoo Cat#: 564978 | Name: JTS-653

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JTS-653 is an orally active and selective transient receptor potential vanilloid 1 (TRPV1) antagonist.

Chemical Structure

JTS-653

CAS#942614-99-5

Theoretical Analysis

MedKoo Cat#: 564978

Name: JTS-653

CAS#: 942614-99-5

Chemical Formula: C23H21F3N4O4

Exact Mass: 474.1515

Molecular Weight: 474.44

Elemental Analysis: C, 58.23; H, 4.46; F, 12.01; N, 11.81; O, 13.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

JTS653; JTS 653; JTS-653

IUPAC/Chemical Name

(3S)-3-(Hydroxymethyl)-4-(5-methylpyridin-2-yl)-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide

InChi Key

QZUCKCLSVBFSOS-INIZCTEOSA-N

InChi Code

InChI=1S/C23H21F3N4O4/c1-14-5-7-19(27-9-14)30-16(11-31)12-33-21-17(3-2-4-18(21)30)22(32)29-15-6-8-20(28-10-15)34-13-23(24,25)26/h2-10,16,31H,11-13H2,1H3,(H,29,32)/t16-/m0/s1

SMILES Code

O=C(C1=C2OC[C@H](CO)N(C3=NC=C(C)C=C3)C2=CC=C1)NC4=CC=C(OCC(F)(F)F)N=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 474.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kitagawa Y, Tamai I, Hamada Y, Usui K, Wada M, Sakata M, Matsushita M. Orally administered selective TRPV1 antagonist, JTS-653, attenuates chronic pain refractory to non-steroidal anti-inflammatory drugs in rats and mice including post-herpetic pain. J Pharmacol Sci. 2013;122(2):128-37. Epub 2013 Jun 1. PubMed PMID: 23728381. 2: Kitagawa Y, Wada M, Kanehisa T, Miyai A, Usui K, Maekawa M, Sakata M, Matsuo A, Hayashi M, Matsushita M. JTS-653 blocks afferent nerve firing and attenuates bladder overactivity without affecting normal voiding function. J Urol. 2013 Mar;189(3):1137-46. doi: 10.1016/j.juro.2012.09.055. Epub 2012 Oct 8. PubMed PMID: 22999996. 3: Kitagawa Y, Miyai A, Usui K, Hamada Y, Deai K, Wada M, Koga Y, Sakata M, Hayashi M, Tominaga M, Matsushita M. Pharmacological characterization of (3S)-3-(hydroxymethyl)-4-(5-methylpyridin-2-yl)-N-[6-(2,2,2-trifluoroethoxy)pyrid in-3-yl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide (JTS-653), a novel transient receptor potential vanilloid 1 antagonist. J Pharmacol Exp Ther. 2012 Aug;342(2):520-8. doi: 10.1124/jpet.112.194027. Epub 2012 May 15. PubMed PMID: 22588258.