Synonym
BGC20-1531 HCl; BGC20-1531 hydrochloride; BGC20-1531; BGC 20-1531; BGC-20-1531; BGC201531; BGC 201531; BGC-201531; PGN 1531; PGN-1531; PGN1531;
IUPAC/Chemical Name
4-[[4-(5-methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide, monohydrochloride
InChi Key
ZSHYZCXOFPPBMH-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H24N2O6S.ClH/c1-17-6-4-5-7-25(17)35(30,31)28-26(29)24-14-20(18(2)34-24)16-33-21-10-8-19(9-11-21)23-13-12-22(32-3)15-27-23;/h4-15H,16H2,1-3H3,(H,28,29);1H
SMILES Code
O=C(C1=CC(COC2=CC=C(C3=NC=C(OC)C=C3)C=C2)=C(C)O1)NS(=O)(C4=CC=CC=C4C)=O.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
529.00
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Antonova M. Prostaglandins and prostaglandin receptor antagonism in migraine.
Dan Med J. 2013 May;60(5):B4635. Review. PubMed PMID: 23673269.
2: Antonova M, Wienecke T, Maubach K, Thomas E, Olesen J, Ashina M. The
pharmacological effect of BGC20-1531, a novel prostanoid EP4 receptor antagonist,
in the prostaglandin E2 human model of headache. J Headache Pain. 2011
Oct;12(5):551-9. doi: 10.1007/s10194-011-0358-9. Epub 2011 Jun 17. PubMed PMID:
21681585; PubMed Central PMCID: PMC3173651.
3: Maubach KA, Davis RJ, Clark DE, Fenton G, Lockey PM, Clark KL, Oxford AW,
Hagan RM, Routledge C, Coleman RA. BGC20-1531, a novel, potent and selective
prostanoid EP receptor antagonist: a putative new treatment for migraine
headache. Br J Pharmacol. 2009 Jan;156(2):316-27. doi:
10.1111/j.1476-5381.2009.00027.x. Epub 2009 Jan 19. PubMed PMID: 19154437; PubMed
Central PMCID: PMC2697835.
