Navafenterol saccharinate | CAS# 1648550-37-1 | Bronchodilator

MedKoo Cat#: 573396 | Name: Navafenterol saccharinate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Navafenterol, also known as AZD-8871, is a new chemical entity possessing long-acting effect in a single molecule which presents a novel treatment approach to chronic obstructive pulmonary disease [COPD] and potentially also asthma (in combination with an inhaled corticosteroid [ICS]).

Chemical Structure

Navafenterol saccharinate

CAS#1648550-37-1 ( saccharinate)

Theoretical Analysis

MedKoo Cat#: 573396

Name: Navafenterol saccharinate

CAS#: 1648550-37-1 ( saccharinate)

Chemical Formula: C45H47N7O9S3

Exact Mass: 925.2597

Molecular Weight: 926.09

Elemental Analysis: C, 58.36; H, 5.12; N, 10.59; O, 15.55; S, 10.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1648550-37-1 ( saccharinate) 1435519-06-4 (free base)

Synonym

AZD-8871 saccharinate; AZD-8871; AZD 8871; AZD8871; LAS-191351; LAS 191351; LAS191351; Navafenterol

IUPAC/Chemical Name

(1r,4r)-4-((3-(5-((((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-1H-benzo[d][1,2,3]triazol-1-yl)propyl)(methyl)amino)cyclohexyl 2-hydroxy-2,2-di(thiophen-2-yl)acetate compound with benzo[d]isothiazol-3(2H)-one 1,1-dioxide (1:1)

InChi Key

WXFYZNXSBYPTSS-KYWULLABSA-N

InChi Code

1S/C38H42N6O6S2.C7H5NO3S/c1-43(25-8-10-26(11-9-25)50-37(48)38(49,33-5-2-19-51-33)34-6-3-20-52-34)17-4-18-44-30-14-7-24(21-29(30)41-42-44)22-39-23-32(46)27-12-15-31(45)36-28(27)13-16-35(47)40-36;9-7-5-3-1-2-4-6(5)12(10,11)8-7/h2-3,5-7,12-16,19-21,25-26,32,39,45-46,49H,4,8-11,17-18,22-23H2,1H3,(H,40,47);1-4H,(H,8,9)/t25-,26-,32-;/m0./s1

SMILES Code

O=C(O[C@H]1CC[C@H](N(CCCN2N=NC3=CC(CNC[C@H](O)C4=CC=C(O)C5=C4C=CC(N5)=O)=CC=C32)C)CC1)C(C6=CC=CS6)(O)C7=CC=CS7

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 926.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Singh D, Fuhr R, Jimenez L, Wählby Hamrén U, Jauhiainen A, Malice MP, Balaguer V, Lei A, Aggarwal A, Astbury C, Psallidas I. A Randomized Trial of Dual-Acting Bronchodilator AZD8871 for Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2019 Feb 15. doi: 10.1164/rccm.201812-2345LE. [Epub ahead of print] PubMed PMID: 30768909.