MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 564883 | Name: CXN37378

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CXN37378, also known as NAP, is a potent and selective antagonist for the μ-opioid receptor (MOR). This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

CXN37378
CXN37378
CAS#1236037-37-8 (free base)

Theoretical Analysis

MedKoo Cat#: 564883

Name: CXN37378

CAS#: 1236037-37-8 (free base)

Chemical Formula: C27H31N3O4

Exact Mass: 461.2315

Molecular Weight: 461.56

Elemental Analysis: C, 70.26; H, 6.77; N, 9.10; O, 13.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
1236037-37-8 (free base) 1334287-69-2 (2HCl) 1410856-54-0 ((HCl)
Synonym
NAP, CXN37378; CXN-37378; CXN 37378;
IUPAC/Chemical Name
N-Isonicotinoyl-beta-naltrexamine; N-((4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl)-3-methylisonicotinamide
InChi Key
COQZBDBMRLFDRK-XGTKUTNFSA-N
InChi Code
InChI=1S/C27H31N3O4/c1-15-13-28-10-7-18(15)25(32)29-19-6-8-27(33)21-12-17-4-5-20(31)23-22(17)26(27,24(19)34-23)9-11-30(21)14-16-2-3-16/h4-5,7,10,13,16,19,21,24,31,33H,2-3,6,8-9,11-12,14H2,1H3,(H,29,32)/t19-,21-,24+,26+,27-/m1/s1
SMILES Code
O[C@@]1([C@@]23CC4)[C@@H](CC5=CC=C(O)C(O[C@H]3[C@H](NC(C(C=CN=C6)=C6C)=O)CC1)=C52)N4CC7CC7
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 461.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zheng Y, Obeng S, Wang H, Jali AM, Peddibhotla B, Williams D, Zou C, Stevens DL, Dewey WL, Akbarali HI, Selley DE, Zhang Y. Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'- pyridyl)carboxamido]morphinan (NAP) Derivatives as Mu/Kappa Opioid Receptor Dual Selective Ligands. J Med Chem. 2019 Jan 4. doi: 10.1021/acs.jmedchem.8b01158. [Epub ahead of print] PubMed PMID: 30608693. 2: Zheng Y, Obeng S, Wang H, Stevens DL, Komla E, Selley DE, Dewey WL, Akbarali HI, Zhang Y. Methylation Products of 6β- N-Heterocyclic Substituted Naltrexamine Derivatives as Potential Peripheral Opioid Receptor Modulators. ACS Chem Neurosci. 2018 Jul 23. doi: 10.1021/acschemneuro.8b00234. [Epub ahead of print] PubMed PMID: 30001114; PubMed Central PMCID: PMC6344324.