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MedKoo Cat#: 581740 | Name: Decamethoxine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Decamethoxine is an antimicrobial agent.

Chemical Structure

Decamethoxine
Decamethoxine
CAS#38146-42-8 (chloride)

Theoretical Analysis

MedKoo Cat#: 581740

Name: Decamethoxine

CAS#: 38146-42-8 (chloride)

Chemical Formula: C38H74Cl2N2O4

Exact Mass: 0.0000

Molecular Weight: 693.92

Elemental Analysis: C, 65.77; H, 10.75; Cl, 10.22; N, 4.04; O, 9.22

Price and Availability

Size Price Availability Quantity
5mg USD 150.00 Ready to ship
10mg USD 250.00 Ready to ship
25mg USD 450.00 Ready to ship
50mg USD 750.00 Ready to ship
100mg USD 1,250.00 Ready to ship
200mg USD 1,950.00 Ready to ship
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Related CAS #
17298-14-5 (cation) 38146-42-8 (chloride)
Synonym
Decamethoxine; Dekametoksin; Decametoxin; Septefri; MM 692; MM692; MM-692;
IUPAC/Chemical Name
1,10-Decanediaminium, N,N,N',N'-tetramethyl-N,N'-bis[2-[[5-methyl-2-(1-methylethyl)cyclohexyl]oxy]-2-oxoethyl]-, dichloride
InChi Key
LRQIWRXCHWNNEA-UHFFFAOYSA-L
InChi Code
InChI=1S/C38H74N2O4.2ClH/c1-29(2)33-21-19-31(5)25-35(33)43-37(41)27-39(7,8)23-17-15-13-11-12-14-16-18-24-40(9,10)28-38(42)44-36-26-32(6)20-22-34(36)30(3)4;;/h29-36H,11-28H2,1-10H3;2*1H/q+2;;/p-2
SMILES Code
O=C(OC1C(C(C)C)CCC(C)C1)C[N+](C)(C)CCCCCCCCCC[N+](C)(C)CC(OC2C(C(C)C)CCC(C)C2)=O.[Cl-].[Cl-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
Decamethoxine (Septefril) is a cationic gemini surfactant that exhibits strong bactericidal and fungicidal effects. Decamethoxine modifies the permeability of the microbial cell membrane, resulting in the destruction and death of diverse microorganisms.
In vitro activity:
The development of resistance of collection and freshly isolated S. aureus and C. albicans strains to the antiseptic decamethoxim was studied comparatively in vitro. It was shown that the rate of the resistance development was low. After 20 subcultures in the presence of increasing concentrations of decamethoxin, its sensitivity of S. aureus and C. albicans decreased 16-32 and 16-fold respectively. Reference: Antibiot Khimioter. 1992 Dec. https://pubmed.ncbi.nlm.nih.gov/1304128/
In vivo activity:
Intramuscular injection of decamethoxin into the animals in a dose of 0.5 and 1 mg/kg, specifically in a dose of 1 mg/kg, reduced the level of glucose as well as that of total and free glycogen in the liver. The drug lowered also the activity of phosphorylase and glocoso-6-phosphatase. he animals given decamethoxin showed the aforesaid parameters returning to normal 20 days after the drug was discontinued. Reference: Farmakol Toksikol. Jul-Aug 1979;42(4):406-9. https://pubmed.ncbi.nlm.nih.gov/477963/

Preparing Stock Solutions

The following data is based on the product molecular weight 693.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Paliĭ GK, Mrug VM. Issledovanie ustoĭchivosti gospital'nykh shtammov mikroorganizmov k antibiotikam i antiseptikam [Resistance of hospital strains of microorganisms to antibiotics and antiseptics]. Antibiot Khimioter. 1992 Dec;37(12):36-8. Russian. PMID: 1304128. 2. Shchetina VN, Belanov EF, Starobinets ZG, Volianskiĭ IuL. Vliianie dekametoksina na tselostnost' tsitoplazmaticheskoĭ membrany grampolozhitel'nykh i gramotritsatel'nykh mikroorganizmov [The effect of dexamethoxin on the integrity of cytoplasmic membrane in gram-positive and gram-negative microorganisms]. Mikrobiol Zh. 1990 May-Jun;52(3):24-8. Russian. PMID: 2120553. 3. . Kovtuniak NA, Bordiakovskaia LG, Stadniĭchuk RF. Vliianie dekametoksina, dekamina i levorina na soderzhanie kholesterina, fosfolipidov i triglitseridov v pecheni belykh krys [Effect of decamethoxine, decamine and levorin on the content of cholesterol, phospholipids and triglycerides in albino rat liver]. Farmakol Toksikol. 1983 Sep-Oct;46(5):72-5. Russian. PMID: 6628663. 4. Meshchishetn IF, Iarmol'chuk GM. Sravnitel'noe izuchenie vliianiia dekametoksina, dekamina i levorina na pokazateli uglevodnogo obmena v pecheni belykh krys [Comparative study of the effect of decamethoxine, decamine and levorin on carbohydrate metabolic indices in the liver of white rats]. Farmakol Toksikol. 1979 Jul-Aug;42(4):406-9. Russian. PMID: 477963.
In vitro protocol:
1. Paliĭ GK, Mrug VM. Issledovanie ustoĭchivosti gospital'nykh shtammov mikroorganizmov k antibiotikam i antiseptikam [Resistance of hospital strains of microorganisms to antibiotics and antiseptics]. Antibiot Khimioter. 1992 Dec;37(12):36-8. Russian. PMID: 1304128. 2. Shchetina VN, Belanov EF, Starobinets ZG, Volianskiĭ IuL. Vliianie dekametoksina na tselostnost' tsitoplazmaticheskoĭ membrany grampolozhitel'nykh i gramotritsatel'nykh mikroorganizmov [The effect of dexamethoxin on the integrity of cytoplasmic membrane in gram-positive and gram-negative microorganisms]. Mikrobiol Zh. 1990 May-Jun;52(3):24-8. Russian. PMID: 2120553.
In vivo protocol:
1. Kovtuniak NA, Bordiakovskaia LG, Stadniĭchuk RF. Vliianie dekametoksina, dekamina i levorina na soderzhanie kholesterina, fosfolipidov i triglitseridov v pecheni belykh krys [Effect of decamethoxine, decamine and levorin on the content of cholesterol, phospholipids and triglycerides in albino rat liver]. Farmakol Toksikol. 1983 Sep-Oct;46(5):72-5. Russian. PMID: 6628663. 2. Meshchishetn IF, Iarmol'chuk GM. Sravnitel'noe izuchenie vliianiia dekametoksina, dekamina i levorina na pokazateli uglevodnogo obmena v pecheni belykh krys [Comparative study of the effect of decamethoxine, decamine and levorin on carbohydrate metabolic indices in the liver of white rats]. Farmakol Toksikol. 1979 Jul-Aug;42(4):406-9. Russian. PMID: 477963.
1: Fuss J, Palii V, Voloboyeva A. Evaluating the Effectivenes of Antiseptic Solution Decasan in Treatment of Necrotic Soft Tisue Diseases. Pol Przegl Chir. 2016 Oct 1;88(5):233-237. doi: 10.1515/pjs-2016-0058. PubMed PMID: 27811344. 2: Nazarchuk OA. [АNTISEPTICS: MODERN STRATEGY OF STRUGGLE WITH CAUSING AGENTS OF THE ІNFECTION COMPLICATIONS]. Klin Khir. 2016;(9):59-61. Ukrainian. PubMed PMID: 30265488. 3: Arseniuk VV, Bartosh AM, Vasul'ianov DS, Voĭtenko II, Hryniv OV, Smotrov MI. [Probability of incidence of abdominal adhesional process in peritonitis, depending on the sanation preparation applied]. Klin Khir. 2014 Dec;(12):78. Ukrainian. PubMed PMID: 25842895. 4: Paliĭ GK, Nazarchuk AA, Kulakov AI, Nazarchuk GG, Paliĭ DV, Bereza BN, Oleĭnik DP. [Kinetics of decamethoxine, an antimicrobial agent]. Antibiot Khimioter. 2014;59(3-4):7-9. Russian. PubMed PMID: 25300114. 5: Nazirov FN, Aripova NU, Makhkamova MN, Dzhamalov SI, Pulatov MM, Magzumov IKh, Isroilov BN. [Use of antiseptic dekasan in complex treatment of peritonitis]. Klin Khir. 2014 Jan;(1):26-7. Russian. PubMed PMID: 24923145. 6: Aripova NU, Magzumov IKh. [Sanation of biliary system using antiseptic decasan in complex treatment of cholangitis]. Klin Khir. 2014 Feb;(2):20-2. Russian. PubMed PMID: 24923115. 7: Nazarchuk OA, Vernyhorods'kyĭ SV, Paliĭ VH, Nazarchuk HH, Paliĭ DV, Honchar OO, Zadereĭ NV. [Local impact of antiseptic medical textile on tissues of organism]. Klin Khir. 2013 Jul;(7):61-4. Ukrainian. PubMed PMID: 24283049. 8: Boĭko VV, Lohachev VK, Tymchenko MIe. [Application of decamethoxin solution in the treatment of surgical peritonitis]. Klin Khir. 2012 Dec;(12):16-9. Ukrainian. PubMed PMID: 23610813. 9: Paliĭ GK, Nazarchuk AA, Paliĭ DV, Nazarchuk GG, Gonchar OO, Sukhliak VV, Trofimenko IuIu, Zadereĭ NV, Stukan OK. [Antimicrobial properties of antiseptic composite with prolonged action]. Antibiot Khimioter. 2013;58(3-4):14-8. Russian. PubMed PMID: 24640146. 10: Zakharash MP, Kucher ND, Krivoruk MI, Iaremchuk IA. [Application of antiseptic decasan in purulent infections of pararectal region]. Klin Khir. 2011 Apr;(4):18-20. Russian. PubMed PMID: 21698929. 11: Nichitaĭlo ME. [Dekasan application in treatment of infected pancreatic necrosis and its complications]. Klin Khir. 2010 Mar;(3):50-1. Russian. PubMed PMID: 20491259. 12: Fomin PD, Lissov AI, Kozlov SN, Mikhal'chishin SN. [Application of antiseptic dekasan in urgent abdominal surgery]. Klin Khir. 2009 Nov-Dec;(11-12):98-100. Russian. PubMed PMID: 20458953. 13: Konovalov EP, Terletskiĭ VN, Pliatsok AA, Gumeniuk NI, Padiĭ VI, Iakovlev BF. [Application of the Decasan at the practice of urgent surgery]. Klin Khir. 2004 Sep;(9):18-20. Russian. PubMed PMID: 15560593. 14: Dykyĭ IL, Zaĭtsev OI, Filimonova NI. [Microbiological validation of the composition of "decaceol", an antiseptic prolonged-release drug]. Lik Sprava. 2002;(7):114-7. Ukrainian. PubMed PMID: 12587327. 15: Shapryns'kyĭ VO. [Intestinal decompression and correction of enteral insufficiency in postoperative peritonitis]. Klin Khir. 1998;(2):8-9. Ukrainian. PubMed PMID: 9615064. 16: Paliĭ GK, Zheliba ND, Shevnia PS, Kravets VP, Koval'chuk VP, Makats EF. [The use of new drug forms of decamethoxin for the prevention and treatment of postinjection complications]. Klin Khir. 1995;(2):8-9. Russian. PubMed PMID: 9053212. 17: Bievskiĭ AN. [The action of quaternary ammonium derivatives on respiration and nitrate reduction in Pseudomonas aeruginosa]. Mikrobiol Z. 1994 Mar-Apr;56(2):7-11. Russian. PubMed PMID: 7952225. 18: Paliĭ GK, Koval'chuk VP, Kravets VP, Paliĭ IG, Shevnia PS. [A comparative study of the efficacy of antiseptics used for preventing infectious complications]. Klin Khir. 1993;(1):11-3. Russian. PubMed PMID: 10912016. 19: Paliĭ GK, Barilo AS, Chesnokova AA. [Comparative effectiveness of antimicrobial action of antiseptics against pathogens of chronic purulent otitis media]. Antibiot Khimioter. 1992 Dec;37(12):50-2. Russian. PubMed PMID: 1304133. 20: Paliĭ GK, Mrug VM. [Resistance of hospital strains of microorganisms to antibiotics and antiseptics]. Antibiot Khimioter. 1992 Dec;37(12):36-8. Russian. PubMed PMID: 1304128.