LLY-507 is a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. SMYD2 is a lysine methyltransferase that catalyzes the monomethylation of several protein substrates including p53. LLY-507 is >100-fold selective for SMYD2 over a broad range of methyltransferase and non-methyltransferase targets. LLY-507 is active in cells as measured by reduction of SMYD2-induced monomethylation of p53 Lys(370) at submicromolar concentrations. LLY-507 inhibited the proliferation of several esophageal, liver, and breast cancer cell lines in a dose-dependent manner.
MedKoo Cat#: 407330
Name: LLY-507
CAS#: 1793053-37-8
Chemical Formula: C36H42N6O
Exact Mass: 574.3420
Molecular Weight: 574.77
Elemental Analysis: C, 75.23; H, 7.37; N, 14.62; O, 2.78
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.5 | 39.15 | |
| DMF | 10.0 | 17.40 | |
| Ethanol | 23.5 | 40.89 |
The following data is based on the product molecular weight 574.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
