MedKoo Cat#: 555406 | Name: EVT-101 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EVT-101, also known as ENS-101, is an experimental medication which originated from Roche and is under development by Evotec AG for the treatment of major depressive disorder. It acts as a selective NMDA receptor subunit 2B (NR2B) antagonist.

Chemical Structure

EVT-101 free base
EVT-101 free base
CAS#627525-33-1 (free base)

Theoretical Analysis

MedKoo Cat#: 555406

Name: EVT-101 free base

CAS#: 627525-33-1 (free base)

Chemical Formula: C16H13F3N4

Exact Mass: 318.1092

Molecular Weight: 318.30

Elemental Analysis: C, 60.38; H, 4.12; F, 17.91; N, 17.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
Synonym
EVT-101 free base; EVT-101; EVT 101; EVT101; ENS-101; ENS 101; ENS101;
IUPAC/Chemical Name
5-(3-Difluoromethyl-4-fluorophenyl)-3-(2-methylimidazol-1-ylmethyl)pyridazine
InChi Key
BOVUHBFXPNLTKF-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H13F3N4/c1-10-20-4-5-23(10)9-13-6-12(8-21-22-13)11-2-3-15(17)14(7-11)16(18)19/h2-8,16H,9H2,1H3
SMILES Code
CC1=NC=CN1CC2=NN=CC(C3=CC=C(F)C(C(F)F)=C3)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 318.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wilkinson ST, Sanacora G. A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems. Drug Discov Today. 2018 Nov 14. pii: S1359-6446(18)30376-3. doi: 10.1016/j.drudis.2018.11.007. [Epub ahead of print] Review. PubMed PMID: 30447328. 2: Stroebel D, Buhl DL, Knafels JD, Chanda PK, Green M, Sciabola S, Mony L, Paoletti P, Pandit J. A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists. Mol Pharmacol. 2016 May;89(5):541-51. doi: 10.1124/mol.115.103036. Epub 2016 Feb 24. PubMed PMID: 26912815; PubMed Central PMCID: PMC4859819. 3: Fernandes A, Wojcik T, Baireddy P, Pieschl R, Newton A, Tian Y, Hong Y, Bristow L, Li YW. Inhibition of in vivo [(3)H]MK-801 binding by NMDA receptor open channel blockers and GluN2B antagonists in rats and mice. Eur J Pharmacol. 2015 Nov 5;766:1-8. doi: 10.1016/j.ejphar.2015.08.044. Epub 2015 Aug 29. PubMed PMID: 26325093.