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MedKoo Cat#: 564723 | Name: DPP8/9-IN-8j

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DPP8/9-IN-8j is a selective DPP8/9 inhibitor which blocks AML progression in vivo.

Chemical Structure

DPP8/9-IN-8j
DPP8/9-IN-8j
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564723

Name: DPP8/9-IN-8j

CAS#: NONE

Chemical Formula: C14H19FN2O

Exact Mass: 250.1481

Molecular Weight: 250.32

Elemental Analysis: C, 67.18; H, 7.65; F, 7.59; N, 11.19; O, 6.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DPP8/9 IN-8j; DPP8/9-IN8j; DPP8/9-IN-8j
IUPAC/Chemical Name
(2S,3R)-2-Amino-1-(5-fluoroisoindolin-2-yl)-3-methylpentan-1-one
InChi Key
MMZVCOZOFNZWBM-RNCFNFMXSA-N
InChi Code
InChI=1S/C14H19FN2O/c1-3-9(2)13(16)14(18)17-7-10-4-5-12(15)6-11(10)8-17/h4-6,9,13H,3,7-8,16H2,1-2H3/t9-,13+/m1/s1
SMILES Code
CC[C@@H](C)[C@H](N)C(N1CC2=C(C=C(F)C=C2)C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 250.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhong FL, Robinson K, Teo DET, Tan KY, Lim C, Harapas CR, Yu CH, Xie WH, Sobota RM, Au VB, Hopkins R, D'Osualdo A, Reed JC, Connolly JE, Masters SL, Reversade B. Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding. J Biol Chem. 2018 Dec 7;293(49):18864-18878. doi: 10.1074/jbc.RA118.004350. Epub 2018 Oct 5. PubMed PMID: 30291141; PubMed Central PMCID: PMC6295727. 2: Brunetti M, Holth A, Panagopoulos I, Staff AC, Micci F, Davidson B. Expression and clinical role of the dipeptidyl peptidases DPP8 and DPP9 in ovarian carcinoma. Virchows Arch. 2018 Nov 22. doi: 10.1007/s00428-018-2487-x. [Epub ahead of print] PubMed PMID: 30467600. 3: Koyani CN, Trummer C, Shrestha N, Scheruebel S, Bourgeois B, Plastira I, Kickmaier S, Sourij H, Rainer PP, Madl T, Sattler W, Pelzmann B, Malle E, von Lewinski D. Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes. Front Physiol. 2018 Nov 14;9:1622. doi: 10.3389/fphys.2018.01622. eCollection 2018. PubMed PMID: 30487758; PubMed Central PMCID: PMC6246635.