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MedKoo Cat#: 573249 | Name: Physostigmine methiodide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Physostigmine methiodide is a reversible carbamate cholinesterase inhibitor which may have channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex.

Chemical Structure

Physostigmine methiodide
Physostigmine methiodide
CAS#6091-11-8 (HI)

Theoretical Analysis

MedKoo Cat#: 573249

Name: Physostigmine methiodide

CAS#: 6091-11-8 (HI)

Chemical Formula: C16H24IN3O2

Exact Mass: 0.0000

Molecular Weight: 417.29

Elemental Analysis: C, 46.05; H, 5.80; I, 30.41; N, 10.07; O, 7.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
64-47-1 (sulfate) 57-47-6 (free base) 6091-12-9 (HCl) 6091-13-0 (HBr) 57-64-7 (salicylate) 6091-11-8 (HI)
Synonym
Physostigmine methiodide
IUPAC/Chemical Name
(3aS,8aR)-1,3a,8,8-tetramethyl-5-((methylcarbamoyl)oxy)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-8-ium iodide
InChi Key
SLSBBKOEHGUBBZ-XMZRARIVSA-N
InChi Code
1S/C16H23N3O2.HI/c1-16-8-9-18(3)14(16)19(4,5)13-7-6-11(10-12(13)16)21-15(20)17-2;/h6-7,10,14H,8-9H2,1-5H3;1H/t14-,16+;/m1./s1
SMILES Code
[N+]1(C)(c2c([C@@]3([C@@H]1[N@@](C)CC3)C)cc(OC(=O)NC)cc2)C.[IH-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 417.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shaw KP, Aracava Y, Akaike A, Daly JW, Rickett DL, Albuquerque EX. The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex. Mol Pharmacol. 1985 Dec;28(6):527-38. PubMed PMID: 2417099.