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MedKoo Cat#: 597340 | Name: PHYD protein, Arabidopsis

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PHYD protein, Arabidopsis belongs to the phytochrome apoprotein family in Arabidopsis; GenBank X76609.

Chemical Structure

PHYD protein, Arabidopsis
PHYD protein, Arabidopsis
CAS#158379-16-9

Theoretical Analysis

MedKoo Cat#: 597340

Name: PHYD protein, Arabidopsis

CAS#: 158379-16-9

Chemical Formula: C61H96N16O19S

Exact Mass: 1388.6758

Molecular Weight: 1389.59

Elemental Analysis: C, 52.73; H, 6.96; N, 16.13; O, 21.88; S, 2.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PHYD protein, Arabidopsis; Phyd gene product; Phyd protein;
IUPAC/Chemical Name
(2S,5S,8S,11S,14S,17S,20S,23S,26S)-2-((1H-imidazol-4-yl)methyl)-26-((2S,3S)-2-((S)-2-amino-4-(methylthio)butanamido)-3-methylpentanamido)-17-benzyl-23-(2-carboxyethyl)-20-(carboxymethyl)-11-(3-guanidinopropyl)-5-(hydroxymethyl)-8,14-diisobutyl-4,7,10,13,16,19,22,25-octaoxo-3,6,9,12,15,18,21,24-octaazanonacosanedioic acid
InChi Key
UUADODNGTPCSBC-HXBUARKNSA-N
InChi Code
InChI=1S/C61H96N16O19S/c1-8-33(6)49(77-50(85)36(62)20-22-97-7)59(94)70-39(17-19-47(81)82)52(87)69-38(16-18-46(79)80)53(88)74-43(27-48(83)84)57(92)73-42(25-34-13-10-9-11-14-34)56(91)72-40(23-31(2)3)54(89)68-37(15-12-21-66-61(63)64)51(86)71-41(24-32(4)5)55(90)76-45(29-78)58(93)75-44(60(95)96)26-35-28-65-30-67-35/h9-11,13-14,28,30-33,36-45,49,78H,8,12,15-27,29,62H2,1-7H3,(H,65,67)(H,68,89)(H,69,87)(H,70,94)(H,71,86)(H,72,91)(H,73,92)(H,74,88)(H,75,93)(H,76,90)(H,77,85)(H,79,80)(H,81,82)(H,83,84)(H,95,96)(H4,63,64,66)/t33-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,49-/m0/s1
SMILES Code
O=C(O)[C@H](CC1=CNC=N1)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCSC)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,389.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sánchez-Lamas M, Lorenzo CD, Cerdán PD. Bottom-up Assembly of the Phytochrome Network. PLoS Genet. 2016 Nov 7;12(11):e1006413. doi: 10.1371/journal.pgen.1006413. eCollection 2016 Nov. PubMed PMID: 27820825; PubMed Central PMCID: PMC5098793. 2: Hu W, Franklin KA, Sharrock RA, Jones MA, Harmer SL, Lagarias JC. Unanticipated regulatory roles for Arabidopsis phytochromes revealed by null mutant analysis. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1542-7. doi: 10.1073/pnas.1221738110. Epub 2013 Jan 9. PubMed PMID: 23302690; PubMed Central PMCID: PMC3557068. 3: Christians MJ, Gingerich DJ, Hua Z, Lauer TD, Vierstra RD. The light-response BTB1 and BTB2 proteins assemble nuclear ubiquitin ligases that modify phytochrome B and D signaling in Arabidopsis. Plant Physiol. 2012 Sep;160(1):118-34. doi: 10.1104/pp.112.199109. Epub 2012 Jun 25. PubMed PMID: 22732244; PubMed Central PMCID: PMC3440189. 4: Iñigo S, Alvarez MJ, Strasser B, Califano A, Cerdán PD. PFT1, the MED25 subunit of the plant Mediator complex, promotes flowering through CONSTANS dependent and independent mechanisms in Arabidopsis. Plant J. 2012 Feb;69(4):601-12. doi: 10.1111/j.1365-313X.2011.04815.x. Epub 2011 Nov 16. PubMed PMID: 21985558. 5: Mathews S, McBreen K. Phylogenetic relationships of B-related phytochromes in the Brassicaceae: Redundancy and the persistence of phytochrome D. Mol Phylogenet Evol. 2008 Nov;49(2):411-23. doi: 10.1016/j.ympev.2008.07.026. Epub 2008 Aug 19. PubMed PMID: 18768161. 6: Al-Sady B, Ni W, Kircher S, Schäfer E, Quail PH. Photoactivated phytochrome induces rapid PIF3 phosphorylation prior to proteasome-mediated degradation. Mol Cell. 2006 Aug 4;23(3):439-46. PubMed PMID: 16885032. 7: Fernández AP, Gil P, Valkai I, Nagy F, Schäfer E. Analysis of the function of the photoreceptors phytochrome B and phytochrome D in Nicotiana plumbaginifolia and Arabidopsis thaliana. Plant Cell Physiol. 2005 May;46(5):790-6. Epub 2005 Mar 7. PubMed PMID: 15753105. 8: Sharrock RA, Clack T, Goosey L. Differential activities of the Arabidopsis phyB/D/E phytochromes in complementing phyB mutant phenotypes. Plant Mol Biol. 2003 May;52(1):135-42. PubMed PMID: 12825695. 9: Sharrock RA, Clack T, Goosey L. Signaling activities among the Arabidopsis phyB/D/E-type phytochromes: a major role for the central region of the apoprotein. Plant J. 2003 May;34(3):317-26. PubMed PMID: 12713538. 10: Halliday KJ, Whitelam GC. Changes in photoperiod or temperature alter the functional relationships between phytochromes and reveal roles for phyD and phyE. Plant Physiol. 2003 Apr;131(4):1913-20. PubMed PMID: 12692350; PubMed Central PMCID: PMC166947. 11: Kiss JZ, Mullen JL, Correll MJ, Hangarter RP. Phytochromes A and B mediate red-light-induced positive phototropism in roots. Plant Physiol. 2003 Mar;131(3):1411-7. PubMed PMID: 12644690; PubMed Central PMCID: PMC166900. 12: Franklin KA, Praekelt U, Stoddart WM, Billingham OE, Halliday KJ, Whitelam GC. Phytochromes B, D, and E act redundantly to control multiple physiological responses in Arabidopsis. Plant Physiol. 2003 Mar;131(3):1340-6. PubMed PMID: 12644683; PubMed Central PMCID: PMC166893. 13: Halliday KJ, Salter MG, Thingnaes E, Whitelam GC. Phytochrome control of flowering is temperature sensitive and correlates with expression of the floral integrator FT. Plant J. 2003 Mar;33(5):875-85. PubMed PMID: 12609029. 14: Sharrock RA, Clack T. Patterns of expression and normalized levels of the five Arabidopsis phytochromes. Plant Physiol. 2002 Sep;130(1):442-56. PubMed PMID: 12226523; PubMed Central PMCID: PMC166576. 15: Kircher S, Gil P, Kozma-Bognár L, Fejes E, Speth V, Husselstein-Muller T, Bauer D, Adám E, Schäfer E, Nagy F. Nucleocytoplasmic partitioning of the plant photoreceptors phytochrome A, B, C, D, and E is regulated differentially by light and exhibits a diurnal rhythm. Plant Cell. 2002 Jul;14(7):1541-55. PubMed PMID: 12119373; PubMed Central PMCID: PMC150705. 16: Hennig L, Stoddart WM, Dieterle M, Whitelam GC, Schäfer E. Phytochrome E controls light-induced germination of Arabidopsis. Plant Physiol. 2002 Jan;128(1):194-200. PubMed PMID: 11788765; PubMed Central PMCID: PMC148973. 17: Hirschfeld M, Tepperman JM, Clack T, Quail PH, Sharrock RA. Coordination of phytochrome levels in phyB mutants of Arabidopsis as revealed by apoprotein-specific monoclonal antibodies. Genetics. 1998 Jun;149(2):523-35. PubMed PMID: 9611171; PubMed Central PMCID: PMC1460191. 18: Aukerman MJ, Hirschfeld M, Wester L, Weaver M, Clack T, Amasino RM, Sharrock RA. A deletion in the PHYD gene of the Arabidopsis Wassilewskija ecotype defines a role for phytochrome D in red/far-red light sensing. Plant Cell. 1997 Aug;9(8):1317-26. PubMed PMID: 9286109; PubMed Central PMCID: PMC157000. 19: Clack T, Mathews S, Sharrock RA. The phytochrome apoprotein family in Arabidopsis is encoded by five genes: the sequences and expression of PHYD and PHYE. Plant Mol Biol. 1994 Jun;25(3):413-27. PubMed PMID: 8049367.

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