Lyso-PAF C-16 | CAS#52691-62-0

MedKoo Cat#: 530786 | Name: Lyso-PAF C-16

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lyso-PAF C-16, also known as Lyso-gepc is a lipid compound, and a biologically inactive precursor of platelet activating factor. Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway4 or selective acylation with arachidonic acid by a CoA-independent transacylase.

Chemical Structure

Lyso-PAF C-16

CAS#52691-62-0

Theoretical Analysis

MedKoo Cat#: 530786

Name: Lyso-PAF C-16

CAS#: 52691-62-0

Chemical Formula: C24H52NO6P

Exact Mass: 481.3532

Molecular Weight: 481.65

Elemental Analysis: C, 59.85; H, 10.88; N, 2.91; O, 19.93; P, 6.43

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 350.00	2 Weeks
25mg	USD 650.00	2 Weeks

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Related CAS #

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Synonym

Lyso-PAF C-16; Lyso-gepc; Lyso-platelet activating factor C16; LPC O-16:0;

IUPAC/Chemical Name

3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 4,7-dihydroxy-N,N,N-trimethyl-, inner salt, 4-oxide, (R)-

InChi Key

VLBPIWYTPAXCFJ-XMMPIXPASA-N

InChi Code

InChI=1S/C24H52NO6P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-29-22-24(26)23-31-32(27,28)30-21-19-25(2,3)4/h24,26H,5-23H2,1-4H3/t24-/m1/s1

SMILES Code

CCCCCCCCCCCCCCCCOC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Lyso-PAF C-16, also known as Lyso-gepc is a lipid compound, and a biologically inactive precursor of platelet activating factor.

In vitro activity:

Exogenous PAF C-16 inhibited the growth of M. smegmatis inside phagocytic cells of monocytic cell line, THP-1; this effect was partially blocked by PAF receptor antagonists, suggesting the involvement of PAF receptor-mediated signaling pathways. Reference: Front Microbiol. 2020 Jun 10;11:1046. https://pubmed.ncbi.nlm.nih.gov/32587578/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	10.0	20.76
	DMSO	10.0	20.76
	Ethanol	10.0	20.76
	PBS (pH 7.2)	10.0	20.76
	Water	20.0	41.52

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 481.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Riaz MS, Kaur A, Shwayat SN, Behboudi S, Kishore U, Pathan AA. Dissecting the Mechanism of Intracellular Mycobacterium smegmatis Growth Inhibition by Platelet Activating Factor C-16. Front Microbiol. 2020 Jun 10;11:1046. doi: 10.3389/fmicb.2020.01046. PMID: 32587578; PMCID: PMC7297918. 2. Riaz MS, Kaur A, Shwayat SN, Behboudi S, Kishore U, Pathan AA. Direct Growth Inhibitory Effect of Platelet Activating Factor C-16 and Its Structural Analogs on Mycobacteria. Front Microbiol. 2018 Sep 11;9:1903. doi: 10.3389/fmicb.2018.01903. PMID: 30258409; PMCID: PMC6143801.

In vitro protocol:

In vivo protocol:

TBD

1: Li Y, Hou M, Wang JG, Wang T, Wan J, Jiao BH, Lin ZF. Changes of lymph metabolites in a rat model of sepsis induced by cecal ligation and puncture. J Trauma Acute Care Surg. 2012 Dec;73(6):1545-52. doi: 10.1097/TA.0b013e31826fc9e7. PubMed PMID: 23147180. 2: Qian CG, Lee TC, Snyder F. Metabolism of platelet activating factor (PAF) and related ether lipids by neonatal rat myocytes. J Lipid Mediat. 1989 Mar-Apr;1(2):113-23. PubMed PMID: 2519887. 3: Mickelson JK, Simpson PJ, Lucchesi BR. Myocardial dysfunction and coronary vasoconstriction induced by platelet-activating factor in the post-infarcted rabbit isolated heart. J Mol Cell Cardiol. 1988 Jun;20(6):547-61. PubMed PMID: 3216407.