Pyriofenone | CAS#688046-61-9 | fungicide

MedKoo Cat#: 146259 | Name: Pyriofenone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pyriofenone is a fungicide developed for the control of powdery mildew in crops such as grapes, cucurbits, and cereals. It exhibits a novel mode of action by disrupting the formation and function of fungal cell membranes, although its precise molecular target is not fully characterized. Pyriofenone provides both protective and curative activity, making it effective for integrated disease management. Its unique action and low risk of cross-resistance make it a valuable tool in resistance management strategies.

Chemical Structure

Pyriofenone

CAS#688046-61-9

Theoretical Analysis

MedKoo Cat#: 146259

Name: Pyriofenone

CAS#: 688046-61-9

Chemical Formula: C18H20ClNO5

Exact Mass: 365.1030

Molecular Weight: 365.81

Elemental Analysis: C, 59.10; H, 5.51; Cl, 9.69; N, 3.83; O, 21.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Pyriofenone;

IUPAC/Chemical Name

(5-chloro-2-methoxy-4-methylpyridin-3-yl)(2,3,4-trimethoxy-6-methylphenyl)methanone

InChi Key

NMVCBWZLCXANER-UHFFFAOYSA-N

InChi Code

1S/C18H20ClNO5/c1-9-7-12(22-3)16(23-4)17(24-5)13(9)15(21)14-10(2)11(19)8-20-18(14)25-6/h7-8H,1-6H3

SMILES Code

COC1=CC(C)=C(C(=O)C2=C(C)C(Cl)=CN=C2OC)C(OC)=C1OC

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 365.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ogawa M, Nishimura A, Abe Y, Fukumori Y, Suzuki K, Mitani S. Fungicidal spectrum and biological properties of a new fungicide, pyriofenone. J Pestic Sci. 2023 May 20;48(2):65-70. doi: 10.1584/jpestics.D22-068. PMID: 37361489; PMCID: PMC10288004. 2: Zhang X, Liu F, Li D, Guo D, Ma Y, Zhou JJ, Wang D, Chen Z. Pyriofenone Interacts with the Major Facilitator Superfamily Transporter of Phytopathogenic Fungi to Potentially Control Tea Leaf Spot Caused by Lasiodiplodia theobromae. Phytopathology. 2025 Feb;115(2):128-138. doi: 10.1094/PHYTO-08-24-0246-R. Epub 2025 Jan 27. PMID: 39374036. 3: Ogawa M, Nishimura A, Araki S, Abe Y, Kuwahara N, Fukumori Y, Suzuki K, Mitani S. Effect of pyriofenone on the infection processes and cytological features of Blumeria graminis on wheat leaves. J Pestic Sci. 2024 Aug 20;49(3):195-202. doi: 10.1584/jpestics.D24-005. PMID: 39398502; PMCID: PMC11464264. 4: Chung HS, Kabir MH, Abd El-Aty AM, Lee HS, Rahman MM, Chang BJ, Shin HC, Shim JH. Dissipation kinetics and pre-harvest residue limit of pyriofenone in oriental melon (Cucumis melo Var. makuwa) grown under regulated climatic conditions. Biomed Chromatogr. 2017 Oct;31(10). doi: 10.1002/bmc.3965. Epub 2017 Mar 21. PMID: 28233340. 5: European Food Safety Authority (EFSA); Anastassiadou M, Brancato A, Carrasco Cabrera L, Ferreira L, Greco L, Jarrah S, Kazocina A, Leuschner R, Magrans JO, Miron I, Nave S, Pedersen R, Raczyk M, Reich H, Ruocco S, Sacchi A, Santos M, Stanek A, Theobald A, Vagenende B, Verani A. Review of the existing maximum residue levels for pyriofenone according to Article 12 of Regulation (EC) No 396/2005. EFSA J. 2019 Jun 4;17(6):e05711. doi: 10.2903/j.efsa.2019.5711. PMID: 32626334; PMCID: PMC7009201. 6: Kunova A, Pizzatti C, Bonaldi M, Cortesi P. Metrafenone resistance in a population of Erysiphe necator in northern Italy. Pest Manag Sci. 2016 Feb;72(2):398-404. doi: 10.1002/ps.4060. Epub 2015 Jul 14. PMID: 26079510; PMCID: PMC5034827. 7: European Food Safety Authority (EFSA). Reasoned opinion on the modification of the existing maximum residue level (MRL) for pyriofenone in table grapes. EFSA J. 2015 Mar 30;13(3):4071. doi: 10.2903/j.efsa.2015.4071. PMID: 40061602; PMCID: PMC11883099. 8: European Food Safety Authority (EFSA). Scientific support for preparing an EU position for the 52nd Session of the Codex Committee on Pesticide Residues (CCPR). EFSA J. 2021 Aug 17;19(8):e06766. doi: 10.2903/j.efsa.2021.6766. PMID: 34429776; PMCID: PMC8370139. 9: European Food Safety Authority (EFSA). Scientific support for preparing an EU position in the 51st Session of the Codex Committee on Pesticide Residues (CCPR). EFSA J. 2019 Jul 31;17(7):e05797. doi: 10.2903/j.efsa.2019.5797. PMID: 32626398; PMCID: PMC7009168.