KW-7158 | CAS#214764-26-8 | potassium channel activator

MedKoo Cat#: 529426 | Name: KW-7158

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KW-7158 is a potassium channel activator potentially for the treatment of urinary urgency and frequency

Chemical Structure

KW-7158

CAS#214764-26-8

Theoretical Analysis

MedKoo Cat#: 529426

Name: KW-7158

CAS#: 214764-26-8

Chemical Formula: C16H12F3NO5S2

Exact Mass: 419.0109

Molecular Weight: 419.38

Elemental Analysis: C, 45.82; H, 2.88; F, 13.59; N, 3.34; O, 19.07; S, 15.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KW-7158; KW7158; KW 7158

IUPAC/Chemical Name

(S)-N-(5,5-dioxido-10-oxo-4,10-dihydrobenzo[b]thieno[2,3-e]thiepin-9-yl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide

InChi Key

NAFSYPCVPLWHFY-HNNXBMFYSA-N

InChi Code

InChI=1S/C16H12F3NO5S2/c1-15(23,16(17,18)19)14(22)20-9-3-2-4-10-11(9)12(21)13-8(5-6-26-13)7-27(10,24)25/h2-6,23H,7H2,1H3,(H,20,22)/t15-/m0/s1

SMILES Code

O=C(C1=C(NC([C@](C)(O)C(F)(F)F)=O)C=CC=C12)C3=C(C=CS3)CS2(=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 419.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nishiya Y, Yamagata T, Fukuda A, Yokokawa S, Seishi T, Sakuma T, Sasho S, Shimizu Y, Sato H, Sekine S, Kamigaki M, Yoshida T, Shibata K. The anti-overactive bladder activity of KW-7158 is mediated by blocking equilibrative nucleoside transporter-1. Biol Pharm Bull. 2014;37(1):130-6. PubMed PMID: 24162843. 2: Maeda H, Fujita K, Kobayashi H, Ushiki J, Nakanishi T, Tamai I. Novel LC-MS/MS method for simultaneous quantification of KW-7158, a new drug candidate for urinary incontinence and bladder hyperactivity, and its metabolites in rat plasma: a pharmacokinetic study in male and female rats. Arzneimittelforschung. 2012 May;62(5):213-21. doi: 10.1055/s-0032-1301883. PubMed PMID: 22344572. 3: Maeda H, Kodaira H, Fujita K, Kobayashi H, Ushiki J, Nakanishi T, Tamai I. Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[ 3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals. Xenobiotica. 2012 Jul;42(7):649-59. doi: 10.3109/00498254.2011.652993. PubMed PMID: 22324379. 4: Nishiya Y, Yokokawa S, Fukuda A, Yamagata T, Inayoshi A, Obinata M, Shibata K. The generation of rat dorsal root ganglion cell lines to identify the target of KW-7158, a novel treatment for overactive bladder. Neurosci Res. 2011 Nov;71(3):278-88. doi: 10.1016/j.neures.2011.07.1823. PubMed PMID: 21802454. 5: Sculptoreanu A, Yoshimura N, de Groat WC. KW-7158 [(2S)-(+)-3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[ 3,2-c][1]benzothiepin-9-yl)propanamide] enhances A-type K+ currents in neurons of the dorsal root ganglion of the adult rat. J Pharmacol Exp Ther. 2004 Jul;310(1):159-68. PubMed PMID: 15010502. 6: Lu SH, Yamagata T, Atsuki K, Sun L, Smith CP, Yoshimura N, Chancellor MB, de Groat WC. Effect of KW-7158, a putative afferent nerve inhibitor, on bladder and vesico-vascular reflexes in rats. Brain Res. 2002 Aug 9;946(1):72-8. PubMed PMID: 12133596.