Synonym
ZD-0947; AZD-0947; ZD0947; AZD0947; ZD 0947; AZD 0947
IUPAC/Chemical Name
Benzonitrile, 3-(1,4,5,6,7,8-hexahydro-5-oxo-2-(trifluoromethyl)-4-quinolinyl)-, (S)-
InChi Key
RUVMMEREJMHLOS-LBPRGKRZSA-N
InChi Code
InChI=1S/C17H13F3N2O/c18-17(19,20)15-8-12(11-4-1-3-10(7-11)9-21)16-13(22-15)5-2-6-14(16)23/h1,3-4,7-8,12,22H,2,5-6H2/t12-/m0/s1
SMILES Code
N#CC1=CC=CC([C@@H]2C=C(C(F)(F)F)NC3=C2C(CCC3)=O)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
318.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mori K, Yamashita Y, Teramoto N. Effects of ZD0947, a novel and potent ATP-sensitive K(+) channel opener, on smooth muscle-type ATP-sensitive K(+) channels. Eur J Pharmacol. 2016 Nov 15;791:773-779. doi: 10.1016/j.ejphar.2016.09.038. PubMed PMID: 27693800.
2: Yunoki T, Zhu HL, Iwasa K, Tomoda T, Aishima M, Shibata A, Naito S, Teramoto N. Comparative studies of ZD0947, a novel ATP-sensitive K(+) channel opener, on guinea pig detrusor and aortic smooth muscles. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jan;376(5):309-19. PubMed PMID: 18071674.
3: Aishima M, Tomoda T, Yunoki T, Nakano T, Seki N, Yonemitsu Y, Sueishi K, Naito S, Ito Y, Teramoto N. Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes. Br J Pharmacol. 2006 Nov;149(5):542-50. PubMed PMID: 17016513; PubMed Central PMCID: PMC2014675.
4: Abdel-Karim AM, Bialecki RA, Elhilali MM. Effects of ZD6169 and ZD0947, 2 potassium adenosine triphosphate channel openers, on bladder function of spinalized rats. J Urol. 2002 Aug;168(2):837-42. PubMed PMID: 12131377.
5: Chapple CR, Patroneva A, Raines SR. Effect of an ATP-sensitive potassium channel opener in subjects with overactive bladder: a randomized, double-blind, placebo-controlled study (ZD0947IL/0004). Eur Urol. 2006 May;49(5):879-86. PubMed PMID: 16517051.
