Lysine-iodoacetylmethotrexate | CAS#82339-36-4

MedKoo Cat#: 530770 | Name: Lysine-iodoacetylmethotrexate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lysine-iodoacetylmethotrexate if a Folic Acid Antagonist.

Chemical Structure

Lysine-iodoacetylmethotrexate

CAS#82339-36-4

Theoretical Analysis

MedKoo Cat#: 530770

Name: Lysine-iodoacetylmethotrexate

CAS#: 82339-36-4

Chemical Formula: C23H28IN9O4

Exact Mass: 621.1309

Molecular Weight: 621.44

Elemental Analysis: C, 44.45; H, 4.54; I, 20.42; N, 20.29; O, 10.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Lysine-iodoacetylmethotrexate

IUPAC/Chemical Name

L-Lysine, N2-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-N6-(iodoacetyl)-

InChi Key

NDRPUTRIAJPVPS-INIZCTEOSA-N

InChi Code

InChI=1S/C23H28IN9O4/c1-33(12-14-11-28-20-18(29-14)19(25)31-23(26)32-20)15-7-5-13(6-8-15)21(35)30-16(22(36)37)4-2-3-9-27-17(34)10-24/h5-8,11,16H,2-4,9-10,12H2,1H3,(H,27,34)(H,30,35)(H,36,37)(H4,25,26,28,31,32)/t16-/m0/s1

SMILES Code

O=C(O)[C@H](CCCCNC(CI)=O)NC(C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3N=C2)C)C=C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 621.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rosowsky A, Wright JE, Ginty C, Uren J. Methotrexate analogues. 15. A methotrexate analogue designed for active-site-directed irreversible inactivation of dihydrofolate reductase. J Med Chem. 1982 Aug;25(8):960-4. PubMed PMID: 6811744.