Pyriprole | CAS#394730-71-3 | insecticide

MedKoo Cat#: 146291 | Name: Pyriprole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pyriprole is a phenylpyrazole insecticide and acaricide primarily used in veterinary medicine to control fleas and ticks on dogs. It works by blocking GABA-gated chloride channels in the nervous system of parasites, leading to hyperexcitation, paralysis, and death. Pyriprole is typically applied topically and spreads across the animal's skin via the sebaceous glands for prolonged protection.

Chemical Structure

Pyriprole

CAS#394730-71-3

Theoretical Analysis

MedKoo Cat#: 146291

Name: Pyriprole

CAS#: 394730-71-3

Chemical Formula: C18H10Cl2F5N5S

Exact Mass: 492.9954

Molecular Weight: 494.27

Elemental Analysis: C, 43.74; H, 2.04; Cl, 14.34; F, 19.22; N, 14.17; S, 6.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Pyriprole;

IUPAC/Chemical Name

1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((difluoromethyl)thio)-5-((pyridin-2-ylmethyl)amino)-1H-pyrazole-3-carbonitrile

InChi Key

MWMQNVGAHVXSPE-UHFFFAOYSA-N

InChi Code

1S/C18H10Cl2F5N5S/c19-11-5-9(18(23,24)25)6-12(20)14(11)30-16(28-8-10-3-1-2-4-27-10)15(31-17(21)22)13(7-26)29-30/h1-6,17,28H,8H2

SMILES Code

FC(F)SC1=C(NCC2=CC=CC=N2)N(N=C1C#N)C3=C(Cl)C=C(C=C3Cl)C(F)(F)F

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 494.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Barnett S, Luempert L, Schuele G, Quezada A, Strehlau G, Doherty P. Efficacy of pyriprole topical solution against the cat flea, Ctenocephalides felis, on dogs. Vet Ther. 2008 Spring;9(1):4-14. PMID: 18415942. 2: Thomas C, Roques M, Franc M. The effectiveness of a pyriprole (125 mg/ml) and a metaflumizone (150 mg/ml) combined with amitraz (150 mg/ml) spot-on treatment in preventing Phlebotomus perniciosus from feeding on dogs. Parasite. 2008 Mar;15(1):93-6. doi: 10.1051/parasite/2008151093. PMID: 18416253. 3: Bouhsira E, Fysikopoulos A, Franc M. Efficacy of fipronil-(S)-methoprene, metaflumizone combined with amitraz, and pyriprole commercial spot-on products in preventing Culex pipiens pipiens from feeding on dogs. Vet Rec. 2009 Aug 1;165(5):135-7. doi: 10.1136/vr.165.5.135. PMID: 19648637. 4: Schuele G, Barnett S, Bapst B, Cavaliero T, Luempert L, Strehlau G, Young DR, Moran C, Junquera P. Efficacy of a single application of a 12.5% pyriprole topical solution against laboratory infestations with ticks (Ixodes ricinus, Dermacentor reticulatus, and Rhipicephalus sanguineus) on dogs. Vet Parasitol. 2008 Jul 4;154(3-4):311-7. doi: 10.1016/j.vetpar.2008.03.007. Epub 2008 Mar 18. PMID: 18455315. 5: Schuele G, Barnett S, Bapst B, Cavaliero T, Luempert L, Strehlau G, Young DR, Moran C, Junquera P. The effect of water and shampooing on the efficacy of a pyriprole 12.5% topical solution against brown dog tick (Rhipicephalus sanguineus) and cat flea (Ctenocephalides felis) infestations on dogs. Vet Parasitol. 2008 Feb 14;151(2-4):300-11. doi: 10.1016/j.vetpar.2007.10.009. Epub 2007 Oct 23. PMID: 18061355. 6: Fourie JJ, Horak IG, de la Puente Redondo V. Efficacy of a spot-on formulation of pyriprole on dogs infested with Sarcoptes scabiei. Vet Rec. 2010 Sep 18;167(12):442-5. doi: 10.1136/vr.c4456. PMID: 20852247. 7: Remnant EJ, Morton CJ, Daborn PJ, Lumb C, Yang YT, Ng HL, Parker MW, Batterham P. The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster. Insect Biochem Mol Biol. 2014 Nov;54:11-21. doi: 10.1016/j.ibmb.2014.08.008. Epub 2014 Sep 1. PMID: 25193377. 8: Aaen SM, Horsberg TE. A screening of multiple classes of pharmaceutical compounds for effect on preadult salmon lice Lepeophtheirus salmonis. J Fish Dis. 2016 Oct;39(10):1213-23. doi: 10.1111/jfd.12463. Epub 2016 Apr 1. PMID: 27037538. 9: Aaen SM, Hamre LA, Horsberg TE. A screening of medicinal compounds for their effect on egg strings and nauplii of the salmon louse Lepeophtheirus salmonis (Krøyer). J Fish Dis. 2016 Oct;39(10):1201-12. doi: 10.1111/jfd.12462. Epub 2016 Apr 1. PMID: 27038351. 10: Wang ZH, Gong YJ, Jin GH, Li BY, Chen JC, Kang ZJ, Zhu L, Gao YL, Reitz S, Wei SJ. Field-evolved resistance to insecticides in the invasive western flower thrips Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae) in China. Pest Manag Sci. 2016 Jul;72(7):1440-4. doi: 10.1002/ps.4200. Epub 2016 Jan 4. PMID: 26617067.