MedKoo Cat#: 530757 | Name: Lysine N-acetylglutamate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lysine N-acetylglutamate is a bioactive chemical.

Chemical Structure

Lysine N-acetylglutamate
Lysine N-acetylglutamate
CAS#32608-94-9

Theoretical Analysis

MedKoo Cat#: 530757

Name: Lysine N-acetylglutamate

CAS#: 32608-94-9

Chemical Formula: C13H23N3O6

Exact Mass: 317.1587

Molecular Weight: 317.34

Elemental Analysis: C, 49.20; H, 7.31; N, 13.24; O, 30.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Lysine N-acetylglutamate
IUPAC/Chemical Name
Lysine, N2-(N-acetyl-L-alpha-glutamyl)-, L-
InChi Key
LJAYCQIJHAMKDX-UWVGGRQHSA-N
InChi Code
InChI=1S/C13H23N3O6/c1-8(17)15-9(5-6-11(18)19)12(20)16-10(13(21)22)4-2-3-7-14/h9-10H,2-7,14H2,1H3,(H,15,17)(H,16,20)(H,18,19)(H,21,22)/t9-,10-/m0/s1
SMILES Code
NCCCC[C@@H](C(O)=O)NC([C@H](CCC(O)=O)NC(C)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 317.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Green SR, Storey KB. Purification of carbamoyl phosphate synthetase 1 (CPS1) from wood frog (Rana sylvatica) liver and its regulation in response to ice-nucleation and subsequent whole-body freezing. Mol Cell Biochem. 2018 Nov 12. doi: 10.1007/s11010-018-3468-8. [Epub ahead of print] PubMed PMID: 30421312. 2: Dong X, Zhou Z, Wang L, Saremi B, Helmbrecht A, Wang Z, Loor JJ. Increasing the availability of threonine, isoleucine, valine, and leucine relative to lysine while maintaining an ideal ratio of lysine:methionine alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription. J Dairy Sci. 2018 Jun;101(6):5502-5514. doi: 10.3168/jds.2017-13707. Epub 2018 Mar 15. PubMed PMID: 29550128. 3: Liu G, Xiao L, Cao W, Fang T, Jia G, Chen X, Zhao H, Wu C, Wang J. Changes in the metabolome of rats after exposure to arginine and N-carbamylglutamate in combination with diquat, a compound that causes oxidative stress, assessed by 1H NMR spectroscopy. Food Funct. 2016 Feb;7(2):964-74. doi: 10.1039/c5fo01486g. PubMed PMID: 26732548. 4: Ip YK, Loong AM, Chng YR, Hiong KC, Chew SF. Hepatic carbamoyl phosphate synthetase (CPS) I and urea contents in the hylid tree frog, Litoria caerulea: transition from CPS III to CPS I. J Comp Physiol B. 2012 Dec;182(8):1081-94. doi: 10.1007/s00360-012-0682-7. Epub 2012 Jun 27. PubMed PMID: 22736308. 5: Senkevitch E, Cabrera-Luque J, Morizono H, Caldovic L, Tuchman M. A novel biochemically salvageable animal model of hyperammonemia devoid of N-acetylglutamate synthase. Mol Genet Metab. 2012 Jun;106(2):160-8. doi: 10.1016/j.ymgme.2012.03.004. Epub 2012 Mar 17. PubMed PMID: 22503289; PubMed Central PMCID: PMC3356441. 6: Tujioka K, Tuchiya T, Shi X, Ohsumi M, Hayase K, Yokogoshi H. Changes in N-acetylglutamate are involved in regulating urea synthesis in rats given a low gluten diet supplemented with L-lysine, L-methinone and L-threonine. J Nutr Sci Vitaminol (Tokyo). 2009;55(5):417-22. PubMed PMID: 19926928. 7: Rajaram V, Ratna Prasuna P, Savithri HS, Murthy MR. Structure of biosynthetic N-acetylornithine aminotransferase from Salmonella typhimurium: studies on substrate specificity and inhibitor binding. Proteins. 2008 Feb 1;70(2):429-41. PubMed PMID: 17680699. 8: Xu Y, Labedan B, Glansdorff N. Surprising arginine biosynthesis: a reappraisal of the enzymology and evolution of the pathway in microorganisms. Microbiol Mol Biol Rev. 2007 Mar;71(1):36-47. Review. PubMed PMID: 17347518; PubMed Central PMCID: PMC1847373. 9: Chew SF, Ong TF, Ho L, Tam WL, Loong AM, Hiong KC, Wong WP, Ip YK. Urea synthesis in the African lungfish Protopterus dolloi--hepatic carbamoyl phosphate synthetase III and glutamine synthetase are upregulated by 6 days of aerial exposure. J Exp Biol. 2003 Oct;206(Pt 20):3615-24. PubMed PMID: 12966053. 10: Tujioka K, Lyou S, Hirano E, Sano A, Hayase K, Yoshida A, Yokogoshi H. Role of N-acetylglutamate concentration and ornithine transport into mitochondria in urea synthesis of rats given proteins of different quality. J Agric Food Chem. 2002 Dec 4;50(25):7467-71. PubMed PMID: 12452677. 11: Sugahara K, Zhang J, Kodama H. Liquid chromatographic-mass spectrometric analysis of N-acetylamino acids in human urine. J Chromatogr B Biomed Appl. 1994 Jul 1;657(1):15-21. PubMed PMID: 7952062. 12: Kawamoto S, Sonoda T, Ohtake A, Tatibana M. Stimulatory effect of arginine on acetylglutamate synthesis in isolated mitochondria of mouse and rat liver. Biochem J. 1985 Dec 1;232(2):329-34. PubMed PMID: 2868709; PubMed Central PMCID: PMC1152883. 13: Freedland RA, Crozier GL, Hicks BL, Meijer AJ. Arginine uptake by isolated rat liver mitochondria. Biochim Biophys Acta. 1984 Dec 20;802(3):407-12. PubMed PMID: 6150729. 14: Kisumi M, Takagi T, Chibata I. Construction of an L-arginine-producing mutant in Serratia marcescens. Use of the wide substrate specificity of acetylornithinase. J Biochem. 1978 Oct;84(4):881-90. PubMed PMID: 361732.