ZXH-3-26 | CAS#2243076-67-5 | BRD4 Degrader

MedKoo Cat#: 564678 | Name: ZXH-3-26

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZXH-3-26 (CAS No. 2243076-67-5) is a potent and selective PROTAC (Proteolysis Targeting Chimera) compound designed to degrade the bromodomain-containing protein BRD4. It exhibits a DC₅₀/5h value of approximately 5 nM, effectively inducing BRD4 degradation without significantly affecting BRD2 or BRD3. This compound is utilized in research to study the role of BRD4 in various cellular processes and diseases.

Chemical Structure

ZXH-3-26

CAS#2243076-67-5 (free base)

Theoretical Analysis

MedKoo Cat#: 564678

Name: ZXH-3-26

CAS#: 2243076-67-5 (free base)

Chemical Formula: C39H39ClN8O7S

Exact Mass: 798.2351

Molecular Weight: 799.30

Elemental Analysis: C, 58.60; H, 4.92; Cl, 4.44; N, 14.02; O, 14.01; S, 4.01

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 750.00

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Related CAS #

2243076-67-5 (free base) 2307475-86-9 (TFA) ZXH-3-26 HCl

Synonym

ZXH326; ZXH 326; ZXH-326; ZXH 3 26; ZXH-326; ZXH-3-26;

IUPAC/Chemical Name

Methyl 2-((6S)-4-(4-chlorophenyl)-2-((6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)carbamoyl)-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

InChi Key

KLLGWPDWPSUTCL-QBHOUYDASA-N

InChi Code

InChI=1S/C39H39ClN8O7S/c1-20-30-32(22-11-13-23(40)14-12-22)43-26(19-29(50)55-3)34-46-45-21(2)47(34)39(30)56-33(20)36(52)42-18-7-5-4-6-17-41-25-10-8-9-24-31(25)38(54)48(37(24)53)27-15-16-28(49)44-35(27)51/h8-14,26-27,41H,4-7,15-19H2,1-3H3,(H,42,52)(H,44,49,51)/t26-,27?/m0/s1

SMILES Code

O=C(OC)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C(NCCCCCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)S3)C(C7=CC=C(Cl)C=C7)=N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 799.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.