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MedKoo Cat#: 564480 | Name: Silagaba132

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Silagaba132 is a silicon-containing GABA derivative which treats neuropathic pain without central nervous system related side effects.

Chemical Structure

Silagaba132
Silagaba132
CAS#1607006-78-9 (S-isomer)

Theoretical Analysis

MedKoo Cat#: 564480

Name: Silagaba132

CAS#: 1607006-78-9 (S-isomer)

Chemical Formula: C10H21NO2Si

Exact Mass: 215.1342

Molecular Weight: 215.37

Elemental Analysis: C, 55.77; H, 9.83; N, 6.50; O, 14.86; Si, 13.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1607006-78-9 (S-isomer) 1607006-77-8 (R-isomer) 1403674-29-2 (racemic)
Synonym
Silagaba-132; Silagaba 132; Silagaba132
IUPAC/Chemical Name
(S)-3-Aminomethyl-4-(1-methyl-silolan-1-yl)-butyric acid
InChi Key
FBZGGKHJNAORPF-VIFPVBQESA-N
InChi Code
InChI=1S/C10H21NO2Si/c1-14(4-2-3-5-14)8-9(7-11)6-10(12)13/h9H,2-8,11H2,1H3,(H,12,13)/t9-/m0/s1
SMILES Code
O=C(O)C[C@@H](CN)C[Si]1(CCCC1)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 215.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fukasawa H, Muratake H, Ito A, Suzuki H, Amano Y, Nagae M, Sugiyama K, Shudo K. Silicon-containing GABA derivatives, silagaba compounds, as orally effective agents for treating neuropathic pain without central-nervous-system-related side effects. ACS Chem Neurosci. 2014 Jul 16;5(7):525-32. doi: 10.1021/cn500053d. Epub 2014 Apr 30. PubMed PMID: 24738473; PubMed Central PMCID: PMC4102965.