Synonym
Iodoglibenclamide
IUPAC/Chemical Name
Benzamide, N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-5-iodo-2-methoxy
InChi Key
XUABXVPVVXNKND-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H28IN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
SMILES Code
O=C(NCCC1=CC=C(S(=O)(NC(NC2CCCCC2)=O)=O)C=C1)C3=CC(I)=CC=C3OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
585.46
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Clement JP 4th, Kunjilwar K, Gonzalez G, Schwanstecher M, Panten U, Aguilar-Bryan L, Bryan J. Association and stoichiometry of K(ATP) channel subunits. Neuron. 1997 May;18(5):827-38. PubMed PMID: 9182806.
2: Gehlert DR, Gackenheimer SL, Mais DE, Robertson DW. Quantitative autoradiography of the binding sites for [125I] iodoglyburide, a novel high-affinity ligand for ATP-sensitive potassium channels in rat brain. J Pharmacol Exp Ther. 1991 May;257(2):901-7. PubMed PMID: 1903447.
3: Robertson DW, Schober DA, Krushinski JH, Mais DE, Thompson DC, Gehlert DR. Expedient synthesis and biochemical properties of an [125I]-labeled analogue of glyburide, a radioligand for ATP-inhibited potassium channels. J Med Chem. 1990 Dec;33(12):3124-6. PubMed PMID: 2124268.
4: Gehlert DR, Mais DE, Gackenheimer SL, Krushinski JH, Robertson DW. Localization of ATP sensitive potassium channels in the rat brain using a novel radioligand, [125I]iodoglibenclamide. Eur J Pharmacol. 1990 Sep 21;186(2-3):373-5. PubMed PMID: 2127023.
