Synonym
ZK824859; ZK-824859; ZK 824859; ZK824859 HCl; ZK824859 hydrochloride
IUPAC/Chemical Name
(R)-2-((6-((3'-(Aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid dihydrochloride
InChi Key
AQXUHWUZKYSBNO-FAVHNTAZSA-N
InChi Code
InChI=1S/C23H22F2N2O4.2ClH/c1-3-20(23(28)29)31-22-19(25)11-18(24)21(27-22)30-17-8-13(2)7-16(10-17)15-6-4-5-14(9-15)12-26;;/h4-11,20H,3,12,26H2,1-2H3,(H,28,29);2*1H/t20-;;/m1../s1
SMILES Code
CC[C@@H](OC1=NC(OC2=CC(C3=CC=CC(CN)=C3)=CC(C)=C2)=C(F)C=C1F)C(O)=O.[H]Cl.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
501.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Islam I, Yuan S, West CW, Adler M, Bothe U, Bryant J, Chang Z, Chu K, Emayan
K, Gualtieri G, Ho E, Light D, Mallari C, Morser J, Phillips G, Schaefer C,
Sukovich D, Whitlow M, Chen D, Buckman BO. Discovery of selective urokinase
plasminogen activator (uPA) inhibitors as a potential treatment for multiple
sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375. doi:
10.1016/j.bmcl.2018.09.001. Epub 2018 Sep 5. PubMed PMID: 30201291.
