TP0438836 | CAS#957772-01-9 | SGLT1 inhibitor

MedKoo Cat#: 555360 | Name: TP0438836

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TP0438836 is a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor for the treatment of type 2 diabetes. TP0438836 showed IC50 values 28nM and 7 nM for hSGLT1 and hSGLT2 resepctively.

Chemical Structure

TP0438836

CAS#957772-01-9

Theoretical Analysis

MedKoo Cat#: 555360

Name: TP0438836

CAS#: 957772-01-9

Chemical Formula: C27H38N2O10

Exact Mass: 550.2526

Molecular Weight: 550.61

Elemental Analysis: C, 58.90; H, 6.96; N, 5.09; O, 29.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

TP0438836; TP-0438836; TP 0438836;

IUPAC/Chemical Name

1-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-3-(4-(4-hydroxy-2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenethyl)urea

InChi Key

CSTNPWDBBVIJSR-RXFVIIJJSA-N

InChi Code

InChI=1S/C27H38N2O10/c1-15-8-20(34)19(25-24(37)23(36)22(35)21(11-30)39-25)10-18(15)9-17-4-2-16(3-5-17)6-7-28-26(38)29-27(12-31,13-32)14-33/h2-5,8,10,21-25,30-37H,6-7,9,11-14H2,1H3,(H2,28,29,38)/t21-,22-,23+,24-,25+/m1/s1

SMILES Code

O=C(NC(CO)(CO)CO)NCCC1=CC=C(CC2=CC([C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)=C(O)C=C2C)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 550.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kuroda S, Kobashi Y, Oi T, Amada H, Okumura-Kitajima L, Io F, Yamamto K, Kakinuma H. Discovery of a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor (TP0438836) for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3534-3539. doi: 10.1016/j.bmcl.2018.09.035. Epub 2018 Sep 29. PubMed PMID: 30297284.