Squarunkin A is a UNC119-cargo interaction inhibitor. Squarunkin A selectively inhibits the binding of a myristoylated peptide representing the N-terminus of Src kinase to UNC119A with an IC50 value of 10 nm. It binds to UNC119 proteins in cell lysate and interferes with the activation of Src kinase. Squarunkin A inhibition of the UNC119-cargo interaction might provide new opportunities for modulating the activity of Src kinases that are independent of direct inhibition of the enzymatic kinase activity.
MedKoo Cat#: 525261
Name: Squarunkin A
CAS#: 2101958-02-3
Chemical Formula: C25H32F3N5O4
Exact Mass: 523.2406
Molecular Weight: 523.56
Elemental Analysis: C, 57.35; H, 6.16; F, 10.89; N, 13.38; O, 12.22
The following data is based on the product molecular weight 523.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |