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MedKoo Cat#: 564436 | Name: TPP2a bromide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TPP2a is a mitochondrial thioredoxin reductase (TrxR) inhibitor.

Chemical Structure

TPP2a bromide
TPP2a bromide
CAS#1838592-80-5 (bromide)

Theoretical Analysis

MedKoo Cat#: 564436

Name: TPP2a bromide

CAS#: 1838592-80-5 (bromide)

Chemical Formula: C47H52BrO5P

Exact Mass: 806.2736

Molecular Weight: 807.81

Elemental Analysis: C, 69.88; H, 6.49; Br, 9.89; O, 9.90; P, 3.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1838592-80-5 (bromide) 1838592-79-2 (cation)
Synonym
TPP2a; TPP-2a; TPP 2a
IUPAC/Chemical Name
(10-(4-((1E,4Z,6E)-5-Hydroxy-7-(5-methylfuran-2-yl)-3-oxohepta-1,4,6-trien-1-yl)-2-methoxyphenoxy)decyl)triphenylphosphonium bromide
InChi Key
LPFQNDVZJVVEPE-SEOIZWFPSA-N
InChi Code
InChI=1S/C47H51O5P.BrH/c1-38-26-31-42(52-38)32-30-41(49)37-40(48)29-27-39-28-33-46(47(36-39)50-2)51-34-18-7-5-3-4-6-8-19-35-53(43-20-12-9-13-21-43,44-22-14-10-15-23-44)45-24-16-11-17-25-45;/h9-17,20-33,36-37H,3-8,18-19,34-35H2,1-2H3;1H/b29-27+,32-30+;
SMILES Code
COC1=CC(/C=C/C(/C=C(O)/C=C/C2=CC=C(C)O2)=O)=CC=C1OCCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[Br-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 807.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liang B, Shao W, Zhu C, Wen G, Yue X, Wang R, Quan J, Du J, Bu X. Mitochondria-Targeted Approach: Remarkably Enhanced Cellular Bioactivities of TPP2a as Selective Inhibitor and Probe toward TrxR. ACS Chem Biol. 2016 Feb 19;11(2):425-34. doi: 10.1021/acschembio.5b00708. Epub 2015 Dec 14. PubMed PMID: 26653078.