Synonym
ACS67; ACS-67; ACS 67
IUPAC/Chemical Name
5-Heptenoic acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester, (5Z)-
InChi Key
JEEWZRQQYWVJCX-WEWVERJPSA-N
InChi Code
InChI=1S/C32H38O5S3/c33-24(15-12-22-8-4-3-5-9-22)16-19-27-26(28(34)20-29(27)35)10-6-1-2-7-11-31(36)37-25-17-13-23(14-18-25)30-21-32(38)40-39-30/h1,3-6,8-9,13-14,17-18,21,24,26-29,33-35H,2,7,10-12,15-16,19-20H2/b6-1-/t24-,26+,27+,28-,29+/m0/s1
SMILES Code
O=C(OC1=CC=C(C(SS2)=CC2=S)C=C1)CCC/C=C\C[C@@H]3[C@@H](CC[C@@H](O)CCC4=CC=CC=C4)[C@H](O)C[C@@H]3O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
598.83
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Osborne NN, Ji D, Abdul Majid AS, Fawcett RJ, Sparatore A, Del Soldato P. ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture. Invest Ophthalmol Vis Sci. 2010 Jan;51(1):284-94. doi: 10.1167/iovs.09-3999. Epub 2009 Aug 26. PMID: 19710416.
2: Salvi A, Bankhele P, Jamil J, Chitnis MK, Njie-Mbye YF, Ohia SE, Opere CA. Effect of Hydrogen Sulfide Donors on Intraocular Pressure in Rabbits. J Ocul Pharmacol Ther. 2016 Jul-Aug;32(6):371-5. doi: 10.1089/jop.2015.0144. Epub 2016 Apr 19. PMID: 27092593; PMCID: PMC4960495.
3: Olas B. Medical Functions of Hydrogen Sulfide. Adv Clin Chem. 2016;74:195-210. doi: 10.1016/bs.acc.2015.12.007. Epub 2016 Mar 9. PMID: 27117664.
4: Salvi A, Bankhele P, Jamil JM, Kulkarni-Chitnis M, Njie-Mbye YF, Ohia SE, Opere CA. Pharmacological Actions of Hydrogen Sulfide Donors on Sympathetic Neurotransmission in the Bovine Anterior Uvea, In Vitro. Neurochem Res. 2016 May;41(5):1020-8. doi: 10.1007/s11064-015-1784-x. Epub 2015 Dec 23. PMID: 26700431.
5: Tang G, Zhang L, Yang G, Wu L, Wang R. Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells. Diabetologia. 2013 Mar;56(3):533-41. doi: 10.1007/s00125-012-2806-8. Epub 2012 Dec 30. PMID: 23275972.
