Synonym
W-2476; W 2476; W2476
IUPAC/Chemical Name
1-(4-(2-(6-amino-9H-purin-9-yl)ethoxy)phenyl)ethan-1-one
InChi Key
ONZGILNKQYWMNI-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H15N5O2/c1-10(21)11-2-4-12(5-3-11)22-7-6-20-9-19-13-14(16)17-8-18-15(13)20/h2-5,8-9H,6-7H2,1H3,(H2,16,17,18)
SMILES Code
CC(C1=CC=C(OCCN2C=NC3=C(N)N=CN=C23)C=C1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
297.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Li T, Lin GY, Zhong L, Zhou Y, Wang J, Zhu Y, Feng Y, Cai XQ, Liu Q, Nosjean O, Boutin JA, Renard P, Yang DH, Wang MW. W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway. Acta Pharmacol Sin. 2017 Jul;38(7):1024-1037. doi: 10.1038/aps.2017.15. Epub 2017 May 15. PubMed PMID: 28502980; PubMed Central PMCID: PMC5519249.
2: Zhong L, Liu Q, Ting YS, Thien VY, Binti Kalong NS, Yang D, Wang MW. Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression. Chem Biol Drug Des. 2018 Jul 25. doi: 10.1111/cbdd.13371. [Epub ahead of print] PubMed PMID: 30043441.
