Synonym
S 332; GS 332; S332; GS332; S-332; GS-332
IUPAC/Chemical Name
Benzenesulfonamide, 3-methyl-4-(5-oxo-3-phenyl-1-imidazolidinyl)-
InChi Key
HUUHHWPSOFUOEV-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H17N3O3S/c1-12-9-14(23(17,21)22)7-8-15(12)19-11-18(10-16(19)20)13-5-3-2-4-6-13/h2-9H,10-11H2,1H3,(H2,17,21,22)
SMILES Code
O=S(C1=CC=C(N(CN(C2=CC=CC=C2)C3)C3=O)C(C)=C1)(N)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
331.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Iizuka H, Osaka Y, Kondo S, Morita T. Effect of an atypical adrenergic beta3-agonist, GS-332: sodium (2R)-[3-[3-[2-(3-chlorophenyl)-2-hydroxyethylamino]cyclohexyl]phenoxy] acetate, on urinary bladder function in rats. J Smooth Muscle Res. 1998 Aug;34(4):139-49. PubMed PMID: 10102799.
2: Yamanishi T, Yasuda K, Kitahara S, Nakai H, Yoshida K, Iizuka H. Effects of 138-355, a beta3-adrenoceptor selective agonist, on relaxation of the human detrusor muscle in vitro. Neurourol Urodyn. 2006;25(7):815-9. PubMed PMID: 16998863.
3: Morita T, Iizuka H, Iwata T, Kondo S. Function and distribution of beta3-adrenoceptors in rat, rabbit and human urinary bladder and external urethral sphincter. J Smooth Muscle Res. 2000 Feb;36(1):21-32. PubMed PMID: 10830475.
4: Yono M, Yoshida M, Takahashi W, Inadome A, Seshita H, Miyamoto Y, Ueda S. Effects of ovarian hormones on beta-adrenergic receptor-mediated relaxation in the female rabbit bladder. Urol Res. 2000 Jan;28(1):38-45. PubMed PMID: 10732694.
