MedKoo Cat#: 519156 | Name: Isomazole hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isomazole hydrochloride is a cardiotonic.

Chemical Structure

Isomazole hydrochloride
Isomazole hydrochloride
CAS#87359-33-9 (HCl)

Theoretical Analysis

MedKoo Cat#: 519156

Name: Isomazole hydrochloride

CAS#: 87359-33-9 (HCl)

Chemical Formula: C14H14ClN3O2S

Exact Mass: 323.0495

Molecular Weight: 323.80

Elemental Analysis: C, 51.93; H, 4.36; Cl, 10.95; N, 12.98; O, 9.88; S, 9.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Isomazole hydrochloride
IUPAC/Chemical Name
1H-Imidazo(4,5-c)pyridine, 2-(2-methoxy-4-(methylsulfinyl)phenyl)-, monohydrochloride
InChi Key
OJDNVOWLGHYRPR-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H13N3O2S.ClH/c1-19-13-7-9(20(2)18)3-4-10(13)14-16-11-5-6-15-8-12(11)17-14;/h3-8H,1-2H3,(H,16,17);1H
SMILES Code
O=S(C1=CC=C(C(N2)=NC3=C2C=CN=C3)C(OC)=C1)C.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 323.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kelso EJ, McDermott BJ, Silke B. Differential effects of phosphodiesterase inhibitors on accumulation of cyclic AMP in isolated ventricular cardiomyocytes. Biochem Pharmacol. 1995 Feb 14;49(4):441-52. PubMed PMID: 7872950. 2: Kelso EJ, McDermott BJ, Silke B. Cardiotonic actions of selective phosphodiesterase inhibitors in rat isolated ventricular cardiomyocytes. Br J Pharmacol. 1993 Dec;110(4):1387-94. PubMed PMID: 8306078; PubMed Central PMCID: PMC2175870. 3: Hirasawa A, Awaji T, Hosono M, Haruno A, Hashimoto K. Effects of a new forskolin derivative, NKH477, on canine ventricular arrhythmia models. J Cardiovasc Pharmacol. 1993 Dec;22(6):847-51. PubMed PMID: 7509903. 4: Bernstein JR, Franklin RB. High-performance liquid chromatographic assay of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo-[4,5-c] pyridine hydrochloride, a potent cardiotonic agent, and two metabolites in plasma. J Chromatogr. 1985 Jul 12;342(1):228-33. PubMed PMID: 3840172. 5: Robertson DW, Beedle EE, Krushinski JH, Pollock GD, Wilson H, Wyss VL, Hayes JS. Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine. J Med Chem. 1985 Jun;28(6):717-27. PubMed PMID: 4009593. 6: Cameron BD, Draffan GH, Dunsire JP, Zimmer A. The absorption, metabolism and excretion of (14C)-AR-L 115 BS in the baboon. Arzneimittelforschung. 1981;31(1a):217-20. PubMed PMID: 7195225.