Huperzine B is a lycopodium alkaloid isolated from Huperzia serrata that exhibits mild anticholinesterase activity, though it is significantly less potent than huperzine A. It inhibits acetylcholinesterase by reversibly binding to the enzyme’s active site, thereby increasing synaptic acetylcholine levels. While its cognitive-enhancing effects are modest, it is studied for potential neuroprotective roles in models of neurodegenerative disease.
MedKoo Cat#: 112156
Name: Huperzine B
CAS#: 103548-82-9
Chemical Formula: C16H20N2O
Exact Mass: 256.1576
Molecular Weight: 256.35
Elemental Analysis: C, 74.97; H, 7.86; N, 10.93; O, 6.24
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 1.0 | 3.90 | |
| DMSO | 1.0 | 3.90 | |
| Ethanol | 2.0 | 7.80 |
The following data is based on the product molecular weight 256.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
