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MedKoo Cat#: 529151 | Name: Indecainide hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Indecainide hydrochloride is a cardiac depressant.

Chemical Structure

Indecainide hydrochloride
Indecainide hydrochloride
CAS#73681-12-6

Theoretical Analysis

MedKoo Cat#: 529151

Name: Indecainide hydrochloride

CAS#: 73681-12-6

Chemical Formula: C20H25ClN2O

Exact Mass: 344.1655

Molecular Weight: 344.88

Elemental Analysis: C, 69.65; H, 7.31; Cl, 10.28; N, 8.12; O, 4.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Indecainide hydrochloride
IUPAC/Chemical Name
9H-Fluorene-9-carboxamide, 9-(3-((1-methylethyl)amino)propyl)-, monohydrochloride
InChi Key
NXNSCUZKMVYAJQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H24N2O.ClH/c1-14(2)22-13-7-12-20(19(21)23)17-10-5-3-8-15(17)16-9-4-6-11-18(16)20;/h3-6,8-11,14,22H,7,12-13H2,1-2H3,(H2,21,23);1H
SMILES Code
O=C(C1(CCCNC(C)C)C2=C(C3=C1C=CC=C3)C=CC=C2)N.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 344.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Giardina EV, Saroff AL, Schneider M. Effect of indecainide in patients with left ventricular dysfunction. Clin Pharmacol Ther. 1990 Nov;48(5):582-9. PubMed PMID: 2225716. 2: Pratt CM, Francis MJ, Seals AA, Zoghbi W, Young JB. Antiarrhythmic and hemodynamic evaluation of indecainide and procainamide in nonsustained ventricular tachycardia. Am J Cardiol. 1990 Jul 1;66(1):68-74. PubMed PMID: 2193498. 3: Jaillon P, Drici M. Recent antiarrhythmic drugs. Am J Cardiol. 1989 Dec 5;64(20):65J-69J. Review. PubMed PMID: 2688391. 4: Holland DR, Lacefield WB, Gonzales CR, Johnston SR, Turk JA. Indecainide: effects on arrhythmias, electrophysiology, and cardiovascular dynamics. J Cardiovasc Pharmacol. 1989 Sep;14(3):454-61. PubMed PMID: 2476626. 5: Meissner MD, Kay HR, Horowitz LN, Spielman SR, Greenspan AM, Kutalek SP. Relation of acute antiarrhythmic drug efficacy to left ventricular function in coronary artery disease. Am J Cardiol. 1988 May 1;61(13):1050-5. Review. PubMed PMID: 3284319. 6: Salerno DM, Krejci J, Granrud G, Hodges M. Indecainide for treatment of ventricular ectopic depolarizations: efficacy, pharmacokinetics, hemodynamic effects and safety. J Am Coll Cardiol. 1988 Apr;11(4):843-50. PubMed PMID: 3351153. 7: Podrid PJ, Hohnloser S, Lown B. Noninvasive evaluation of indecainide for serious ventricular tachyarrhythmia. Am J Cardiol. 1988 Apr 1;61(10):764-9. PubMed PMID: 2451415. 8: Sandusky GE, Usher RW, Tamura RN. Chronic dietary oncogenicity studies of indecainide in rats and mice. Fundam Appl Toxicol. 1987 Oct;9(3):436-47. PubMed PMID: 3692003. 9: Giardina EG, Zaim S, Saroff AL, Kirschenbaum M. Indecainide compared with quinidine for chronic stable ventricular arrhythmias secondary to coronary artery disease or to cardiomyopathy. Am J Cardiol. 1987 Sep 1;60(7):584-9. PubMed PMID: 2442993. 10: Macina G, Turitto G, Stavens C, Fontaine J, Hariman R, Ursell S, el-Sherif N. Antiarrhythmic effects of oral indecainide in patients with ventricular tachyarrhythmias. Clin Cardiol. 1987 Jun;10(6):357-61. PubMed PMID: 3594958. 11: Nestico PF, Morganroth J, Horowitz LN, Mulhern C. Efficacy of oral and intravenous indecainide in ventricular arrhythmias. Am J Cardiol. 1987 Jun 1;59(15):1332-6. PubMed PMID: 3296725. 12: Miura DS, Wynn J, Keefe D, Laux B, Somberg JC. Antiarrhythmic effects of indecainide in a drug-resistant population with ventricular tachycardia at programmed electrical stimulation. Am Heart J. 1987 Jan;113(1):65-9. PubMed PMID: 3799443. 13: Bernard R, Renard M, Shita A, de Hemptinne J, Gillet JM, Lewinson H, Liebens I, Waterschoot P. [Hemodynamic repercussions and clinical tolerance of 6 class I anti-arrhythmia agents in acute myocardial infarction]. Ann Cardiol Angeiol (Paris). 1986 Apr;35(4):195-8. French. PubMed PMID: 3090925. 14: Dennis PD, Vaughan Williams EM. The effects of indecainide, a new antidysrhythmic drug, on nodal tissues in the isolated rabbit heart. J Cardiovasc Pharmacol. 1986 Jan-Feb;8(1):1-5. PubMed PMID: 2419671. 15: Horowitz LN, Spielman SR, Webb CR, Morganroth J, Greenspan AM. The clinical electrophysiology of intravenous indecainide. Am Heart J. 1985 Oct;110(4):784-8. PubMed PMID: 4050649. 16: Sandusky GE Jr, Meyers DB. Toxicology of indecainide hydrochloride after intravenous administration to rats and dogs. Toxicol Lett. 1985 Aug;26(2-3):107-10. PubMed PMID: 4035704. 17: Dennis PD, Vaughan Williams EM. Effects on rabbit cardiac potentials of aprindine and indecainide, a new antiarrhythmic agent, in normoxia and hypoxia. Br J Pharmacol. 1985 May;85(1):11-9. PubMed PMID: 4027460; PubMed Central PMCID: PMC1916771. 18: Ezri MD, Jacobs LG, Denes P. Unexpected coexistence of supraventricular and ventricular tachycardia in patients with syncope. Pacing Clin Electrophysiol. 1985 May;8(3 Pt 1):329-40. PubMed PMID: 2582378. 19: Farid KZ, Fasola AF, Nash JF. Liquid chromatographic determination of indecainide, a new antiarrhythmic drug, and its major metabolite, desisopropyl indecainide, in biological samples. J Chromatogr. 1985 Feb 8;337(2):329-40. PubMed PMID: 3988863. 20: Sandusky GE Jr, Meyers DB. Toxicology of indecainide hydrochloride in mice, rats, and dogs. Fundam Appl Toxicol. 1985 Feb;5(1):175-81. PubMed PMID: 3921422.

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