MRGPRX1 PAM 1t | CAS#unknown | Modulator

MedKoo Cat#: 208219 | Name: MRGPRX1 PAM 1t

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MRGPRX1 PAM 1t is a positive allosteric modulator (PAM) of MRGPRX1. It has the potential to preferentially activate the receptors at the central terminals of primary sensory neurons and minimize itch side effects caused by peripheral activation.

Chemical Structure

MRGPRX1 PAM 1t

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208219

Name: MRGPRX1 PAM 1t

CAS#: unknown

Chemical Formula: C23H17Cl2F3N2O2S

Exact Mass: 512.0340

Molecular Weight: 513.36

Elemental Analysis: C, 53.81; H, 3.34; Cl, 13.81; F, 11.10; N, 5.46; O, 6.23; S, 6.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

MRGPRX1 PAM1t, MRGPRX1-PAM 1t, MRGPRX1-PAM-1t

IUPAC/Chemical Name

6-(tert-Butyl)-5-(3,4-dichlorophenyl)-4-(2-(trifluoromethoxy)phenoxy)thieno[2,3-d]pyrimidine

InChi Key

VNOJQHCKVSWTKW-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H17Cl2F3N2O2S/c1-22(2,3)19-17(12-8-9-13(24)14(25)10-12)18-20(29-11-30-21(18)33-19)31-15-6-4-5-7-16(15)32-23(26,27)28/h4-11H,1-3H3

SMILES Code

FC(F)(F)OC1=CC=CC=C1OC2=C(C(C3=CC=C(Cl)C(Cl)=C3)=C(C(C)(C)C)S4)C4=NC=N2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 513.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Berhane, Ilyas, et al. "Thieno [2, 3-d] pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1)." Journal of medicinal chemistry 65.4 (2022): 3218-3228.