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MedKoo Cat#: 573137 | Name: Amiloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amiloride is a medication typically used with other medications to treat high blood pressure or swelling due to heart failure or cirrhosis of the liver. In the USA, this drug is available via prescription only.

Chemical Structure

Amiloride
Amiloride
CAS#2609-46-3 (free base)

Theoretical Analysis

MedKoo Cat#: 573137

Name: Amiloride

CAS#: 2609-46-3 (free base)

Chemical Formula: C6H8ClN7O

Exact Mass: 229.0479

Molecular Weight: 229.63

Elemental Analysis: C, 31.38; H, 3.51; Cl, 15.44; N, 42.70; O, 6.97

Price and Availability

Size Price Availability Quantity
100mg USD 350.00 2 Weeks
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Related CAS #
2609-46-3 (free base) 2016-88-8 (HCl anhydrous) 17440-83-4 (HCl hydrate)
Synonym
Amiloride, Amilorida, Amiloridum, Amipramidin, Amipramizid, Guanamprazin
IUPAC/Chemical Name
N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid
InChi Key
XSDQTOBWRPYKKA-UHFFFAOYSA-N
InChi Code
1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
SMILES Code
c1(nc(c(nc1N)N)C(NC(N)=N)=O)Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 229.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Roustit M, Genty C, Lepelley M, Blaise S, Fromy B, Cracowski JL, Bosson JL. Amiloride treatment and increased risk of pressure ulcers in hospitalized patients. Br J Clin Pharmacol. 2016 Dec;82(6):1685-1687. doi: 10.1111/bcp.13084. Epub 2016 Sep 18. PubMed PMID: 27639520; PubMed Central PMCID: PMC5099546. 2: Snell HD, Gonzales EB. 5-(N, N-Hexamethylene) amiloride is a GABA-A ρ1 receptor positive allosteric modulator. Channels (Austin). 2016 Nov;10(6):498-506. doi: 10.1080/19336950.2016.1207021. Epub 2016 Jul 1. PubMed PMID: 27367557; PubMed Central PMCID: PMC5034777. 3: Andersen H, Hansen PB, Bistrup C, Nielsen F, Henriksen JE, Jensen BL. Significant natriuretic and antihypertensive action of the epithelial sodium channel blocker amiloride in diabetic patients with and without nephropathy. J Hypertens. 2016 Aug;34(8):1621-9. doi: 10.1097/HJH.0000000000000967. PubMed PMID: 27214087. 4: Massink A, Louvel J, Adlere I, van Veen C, Huisman BJ, Dijksteel GS, Guo D, Lenselink EB, Buckley BJ, Matthews H, Ranson M, Kelso M, IJzerman AP. 5'-Substituted Amiloride Derivatives as Allosteric Modulators Binding in the Sodium Ion Pocket of the Adenosine A2A Receptor. J Med Chem. 2016 May 26;59(10):4769-77. doi: 10.1021/acs.jmedchem.6b00142. Epub 2016 May 10. PubMed PMID: 27124340. 5: Zhao L, Wang S, Du L, Dev J, Zhou L, Liu Z, Chou JJ, OuYang B. Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride. Protein Cell. 2016 Apr;7(4):300-304. doi: 10.1007/s13238-016-0256-7. PubMed PMID: 26951497; PubMed Central PMCID: PMC4818843. 6: Leng TD, Si HF, Li J, Yang T, Zhu M, Wang B, Simon RP, Xiong ZG. Amiloride Analogs as ASIC1a Inhibitors. CNS Neurosci Ther. 2016 Jun;22(6):468-76. doi: 10.1111/cns.12524. Epub 2016 Feb 18. PubMed PMID: 26890278; PubMed Central PMCID: PMC4996284. 7: Miller RL, Denny GO, Knuepfer MM, Kleyman TR, Jackson EK, Salkoff LB, Loewy AD. Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema. Brain Res. 2015 Mar 19;1601:40-51. doi: 10.1016/j.brainres.2014.12.048. Epub 2014 Dec 31. PubMed PMID: 25557402; PubMed Central PMCID: PMC4346418.