Synonym
Desacetamidocolchicine; Deacetylaminocolchicine; DAAC
IUPAC/Chemical Name
Benzo(a)heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-
InChi Key
IPDJRYUVROTJTO-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H22O5/c1-22-16-9-8-14-12(10-15(16)21)6-5-7-13-11-17(23-2)19(24-3)20(25-4)18(13)14/h8-11H,5-7H2,1-4H3
SMILES Code
O=C1C=C2CCCC3=CC(OC)=C(OC)C(OC)=C3C2=CC=C1OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
342.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Roychowdhury M, Sarkar N, Manna T, Bhattacharyya S, Sarkar T, Basusarkar P, Roy S, Bhattacharyya B. Sulfhydryls of tubulin. A probe to detect conformational changes of tubulin. Eur J Biochem. 2000 Jun;267(12):3469-76. PubMed PMID: 10848962.
2: Banerjee A, D'Hoore A, Engelborghs Y. Interaction of desacetamidocolchicine, a fast binding analogue of colchicine with isotypically pure tubulin dimers alpha beta II, alpha beta III, and alpha beta IV. J Biol Chem. 1994 Apr 8;269(14):10324-9. PubMed PMID: 8144613.
3: Maity SN, Bhattacharyya B. Properties of B-ring analogues of colchicine. FEBS Lett. 1987 Jun 22;218(1):102-6. PubMed PMID: 3595855.
4: Ghosh Choudhury G, Maity S, Bhattacharyya B, Biswas BB. B-ring of colchicine and its role in taxol-induced tubulin polymerization. FEBS Lett. 1986 Mar 3;197(1-2):31-4. PubMed PMID: 2868923.
5: Choudhury GG, Banerjee A, Bhattacharyya B, Biswas BB. Interaction of colchicine analogues with purified tubulin. FEBS Lett. 1983 Sep 5;161(1):55-9. PubMed PMID: 6884527.
6: Ray K, Bhattacharyya B, Biswas BB. Role of B-ring of colchicine in its binding to tubulin. J Biol Chem. 1981 Jun 25;256(12):6241-4. PubMed PMID: 7240202.
