ZJ01 | PPI Inhibitor

MedKoo Cat#: 564317 | Name: ZJ01

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZJ01 is a Keap1-Nrf2 protein-protein interaction (PPI) inhibitor.

Chemical Structure

ZJ01

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564317

Name: ZJ01

CAS#: NONE

Chemical Formula: C24H23N3O3S

Exact Mass: 433.1460

Molecular Weight: 433.53

Elemental Analysis: C, 66.49; H, 5.35; N, 9.69; O, 11.07; S, 7.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ZJ-01; ZJ 01; ZJ01

IUPAC/Chemical Name

Allyl (Z)-(3-(benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-ylidene)carbamate

InChi Key

HBWNDXAVUPAAIJ-ROMGYVFFSA-N

InChi Code

InChI=1S/C24H23N3O3S/c1-4-13-29-24(28)26-22-18(23-25-19-9-7-8-10-21(19)31-23)14-16-11-12-17(15-20(16)30-22)27(5-2)6-3/h4,7-12,14-15H,1,5-6,13H2,2-3H3/b26-22-

SMILES Code

O=C(OCC=C)/N=C1C(C2=NC3=CC=CC=C3S2)=CC4=C(O/1)C=C(N(CC)CC)C=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 433.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jiang CS, Zhuang CL, Zhu K, Zhang J, Muehlmann LA, Figueiró Longo JP, Azevedo RB, Zhang W, Meng N, Zhang H. Identification of a novel small-molecule Keap1-Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy. J Enzyme Inhib Med Chem. 2018 Dec;33(1):833-841. doi: 10.1080/14756366.2018.1461856. PubMed PMID: 29693453; PubMed Central PMCID: PMC6009974.