Alentemol HBr | CAS#112892-51-0 (HBr) | Dopamine Autoreceptor Agonist

MedKoo Cat#: 592513 | Name: Alentemol HBr

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Alentemol, also known as U-66444B and alentamol, is a selective dopamine autoreceptor agonist described as an antipsychotic. Chromosomal breakage following treatment of CHO-K1 cells in vitro with U-68,553B is due to induction of undercondensation of heterochromatin.

Chemical Structure

Alentemol HBr

CAS#112892-51-0 (HBr)

Theoretical Analysis

MedKoo Cat#: 592513

Name: Alentemol HBr

CAS#: 112892-51-0 (HBr)

Chemical Formula: C19H26BrNO

Exact Mass: 0.0000

Molecular Weight: 364.33

Elemental Analysis: C, 62.64; H, 7.19; Br, 21.93; N, 3.84; O, 4.39

Price and Availability

Size	Price	Availability
1mg	USD 150.00	Ready to Ship
5mg	USD 550.00	Ready to Ship
10mg	USD 950.00	Ready to Ship
25mg	USD 1,650.00	Ready to Ship
50mg	USD 2,950.00	Ready to Ship

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Related CAS #

112892-81-6 (HCl) 112891-97-1 (free base) 112892-51-0 (HBr)

Synonym

Alentemol HBr; Alentemol hydrobromide; Alentemol, alentamol, U-66444B; U 66444B; U66444B;

IUPAC/Chemical Name

2-(dipropylamino)-2,3-dihydro-1H-phenalen-5-ol hydrobromide

InChi Key

FWRWEZVGVJKNMU-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H25NO.BrH/c1-3-8-20(9-4-2)17-10-14-6-5-7-15-12-18(21)13-16(11-17)19(14)15;/h5-7,12-13,17,21H,3-4,8-11H2,1-2H3;1H

SMILES Code

OC1=CC2=C3C(CC(N(CCC)CCC)C2)=CC=CC3=C1.[H]Br

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#Y23X03M18

QC Data

View QC data: current batch, Lot#Y23X03M18

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

Alentemol, also known as U-66444B, is a selective dopamine autoreceptor agonist.

In vitro activity:

TBD

In vivo activity:

U-66444B was evaluated for pre- and postsynaptic effects in dopaminergic (DA) cell body and nerve terminal regions of chloral hydrate anesthetized rats. U-66444B depressed DA neurons in substantia nigra pars compacta and ventral tegmental area with a potency three times that for apomorphine. With a sufficient dose, cells were completely silenced. Reference: J Pharmacol Exp Ther. 1990 Aug;254(2):369-74. https://pubmed.ncbi.nlm.nih.gov/1974631/

Preparing Stock Solutions

The following data is based on the product molecular weight 364.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Piercey MF, Broderick PA, Hoffmann WE, Vogelsang GD. U-66444B and U-68553B, potent autoreceptor agonists at dopaminergic cell bodies and terminals. J Pharmacol Exp Ther. 1990 Aug;254(2):369-74. PMID: 1974631.

In vitro protocol:

TBD

In vivo protocol:

1: Yu RL, Aaron CS, Ulrich RG, Thilagar A, Kumaroo PV, Wang Y. Chromosomal breakage following treatment of CHO-K1 cells in vitro with U-68,553B is due to induction of undercondensation of heterochromatin. Environ Mol Mutagen. 1992;20(3):172-87. doi: 10.1002/em.2850200306. PMID: 1396608. 2: Althaus JS, Decker DE, Von Voigtlander PF, Buxser SE. Effects of dopamine agonists on dopamine secretion from PC12 cells: lack of functional autoreceptor activity. Res Commun Chem Pathol Pharmacol. 1991 May;72(2):131-42. PMID: 1678897. 3: Schwende FJ, Rykert UM. Determination of alentamol hydrobromide, a novel antipsychotic agent, in human blood plasma and urine by high-performance liquid chromatography with fluorescence detection and solid-phase extraction. J Chromatogr. 1991 Apr 19;565(1-2):488-96. doi: 10.1016/0378-4347(91)80415-9. PMID: 1874898. 4: Piercey MF, Broderick PA, Hoffmann WE, Vogelsang GD. U-66444B and U-68553B, potent autoreceptor agonists at dopaminergic cell bodies and terminals. J Pharmacol Exp Ther. 1990 Aug;254(2):369-74. PMID: 1974631.