Synonym
Obidoxime sulfate
IUPAC/Chemical Name
Pyridinium, 1,1'-(oxydimethylene)bis(4-formyl-, disulfate, dioxime
InChi Key
HBBXRXJROXBWSA-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H14N4O3.H2O7S2/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20;1-8(2,3)7-9(4,5)6/h1-10H,11-12H2;(H,1,2,3)(H,4,5,6)
SMILES Code
O/N=C/C1=CC=[N+](COC[N+]2=CC=C(/C=N/O)C=C2)C=C1.[O-]S(=O)(OS(=O)([O-])=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
464.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Ettehadi HA, Ghalandari R, Shafaati A, Foroutan SM. Development of a combined solution formulation of atropine sulfate and obidoxime chloride for autoinjector and evaluation of its stability. Iran J Pharm Res. 2013 Winter;12(Suppl):31-6. PubMed PMID: 24250669; PubMed Central PMCID: PMC3813366.
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6: Lifshitz M, Rotenberg M, Sofer S, Tamiri T, Shahak E, Almog S. Carbamate poisoning and oxime treatment in children: a clinical and laboratory study. Pediatrics. 1994 Apr;93(4):652-5. PubMed PMID: 8134223.
7: Clement JG. Toxicity of the combined nerve agents GB/GF in mice: efficacy of atropine and various oximes as antidotes. Arch Toxicol. 1994;68(1):64-6. PubMed PMID: 8166607.
8: Prandota J, Nienartowicz B, Nowicka J. [Dramatic course of poisoning with a organophosphate compound in a 4-year-old boy treated with obidoxime chloride and atropine sulfate]. Pediatr Pol. 1982 Nov;57(11):975-9. Polish. PubMed PMID: 6763186.
9: Brüner H, Gandawidjaja L, Hettwer H, Oldiges H. [Possible combinations of antidotal therapy in rats following intoxication with phosphoric acid esters (author's transl)]. Arzneimittelforschung. 1977;27(10):1983-8. German. PubMed PMID: 336055.
