MedKoo Cat#: 564118 | Name: NSC745887

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC745887 is an anticancer agent which traps DNA-topoisomerase cleavage and suppresses DcR3-associated signaling pathways. This causes apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade.

Chemical Structure

NSC745887
NSC745887
CAS#54490-26-5

Theoretical Analysis

MedKoo Cat#: 564118

Name: NSC745887

CAS#: 54490-26-5

Chemical Formula: C16H8N2O2

Exact Mass: 260.0586

Molecular Weight: 260.25

Elemental Analysis: C, 73.84; H, 3.10; N, 10.76; O, 12.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NSC-745887; NSC 745887; NSC745887
IUPAC/Chemical Name
Naphtho[2,3-f]quinoxaline-7,12-dione
InChi Key
DGLSEJAACVWJNU-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H8N2O2/c19-15-9-3-1-2-4-10(9)16(20)13-11(15)5-6-12-14(13)18-8-7-17-12/h1-8H
SMILES Code
O=C(C1=CC=C2N=CC=NC2=C1C3=O)C4=C3C=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 260.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fann LY, Chen Y, Chu DC, Weng SJ, Chu HC, Wu ATH, Lee JF, Ali AAA, Chen TC, Huang HS, Ma KH. Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways. Oncotarget. 2017 Dec 27;9(15):11922-11937. doi: 10.18632/oncotarget.23714. eCollection 2018 Feb 23. PubMed PMID: 29552282; PubMed Central PMCID: PMC5844718. 2: Chang YL, Lee HJ, Liu ST, Lin YS, Chen TC, Hsieh TY, Huang HS, Huang SM. Different roles of p53 in the regulation of DNA damage caused by 1,2-heteroannelated anthraquinones and doxorubicin. Int J Biochem Cell Biol. 2011 Dec;43(12):1720-8. doi: 10.1016/j.biocel.2011.08.006. Epub 2011 Aug 12. PubMed PMID: 21856437.