ZL170 | TGFß/BMP Inhibitor

MedKoo Cat#: 558730 | Name: ZL170

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZL170 is a natural inhibitor of TGFß/BMP signaling in triple-negative breast cancer (TNBC). ZL170 suppresses tumor epithelial-mesenchymal transition (EMT), stemness and metastasis.

Chemical Structure

ZL170

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 558730

Name: ZL170

CAS#: NONE

Chemical Formula: C15H11NO4

Exact Mass: 269.0688

Molecular Weight: 269.26

Elemental Analysis: C, 66.91; H, 4.12; N, 5.20; O, 23.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ZL-170; ZL 170; ZL170

IUPAC/Chemical Name

(E)-3-(3,4-Dihydroxybenzylidene)-5-hydroxyindolin-2-one

InChi Key

IZSVICKRWYJKLA-VZUCSPMQSA-N

InChi Code

InChI=1S/C15H11NO4/c17-9-2-3-12-10(7-9)11(15(20)16-12)5-8-1-4-13(18)14(19)6-8/h1-7,17-19H,(H,16,20)/b11-5+

SMILES Code

O=C1NC2=C(C=C(O)C=C2)/C1=C\C3=CC=C(O)C(O)=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 269.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Di L, Liu LJ, Yan YM, Fu R, Li Y, Xu Y, Cheng YX, Wu ZQ. Discovery of a natural small-molecule compound that suppresses tumor EMT, stemness and metastasis by inhibiting TGFβ/BMP signaling in triple-negative breast cancer. J Exp Clin Cancer Res. 2019 Mar 21;38(1):134. doi: 10.1186/s13046-019-1130-2. PubMed PMID: 30898152; PubMed Central PMCID: PMC6429712.