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MedKoo Cat#: 564041 | Name: Erasin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Erasin is a natural potent and selective STAT3 inhibitor.

Chemical Structure

Erasin
Erasin
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564041

Name: Erasin

CAS#: NONE

Chemical Formula: C20H19N3O3

Exact Mass: 349.1426

Molecular Weight: 349.39

Elemental Analysis: C, 68.75; H, 5.48; N, 12.03; O, 13.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Erasin
IUPAC/Chemical Name
(E)-N'-((6-(tert-Butyl)-4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
InChi Key
JHUVYXUBEMYTNO-SSDVNMTOSA-N
InChi Code
InChI=1S/C20H19N3O3/c1-20(2,3)15-6-7-17-16(9-15)18(24)14(12-26-17)11-22-23-19(25)13-5-4-8-21-10-13/h4-12H,1-3H3,(H,23,25)/b22-11+
SMILES Code
O=C(N/N=C/C1=COC2=C(C=C(C(C)(C)C)C=C2)C1=O)C3=CN=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 349.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lis C, Rubner S, Roatsch M, Berg A, Gilcrest T, Fu D, Nguyen E, Schmidt AM, Krautscheid H, Meiler J, Berg T. Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells. Sci Rep. 2017 Dec 12;7(1):17390. doi: 10.1038/s41598-017-17600-x. PubMed PMID: 29234062; PubMed Central PMCID: PMC5727211.