Deoxycytidine | CAS #951-77-9 (free base) | deoxyribonucleoside

MedKoo Cat#: 581328 | Name: Deoxycytidine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Deoxycytidine is a deoxyribonucleoside, a component of deoxyribonucleic acid. It is similar to the ribonucleoside cytidine, but with one hydroxyl group removed from the 2' position. Deoxycytidine can be phosphorylated by deoxycytidine kinase (DCK).

Chemical Structure

Deoxycytidine

CAS#951-77-9 (free base)

Theoretical Analysis

MedKoo Cat#: 581328

Name: Deoxycytidine

CAS#: 951-77-9 (free base)

Chemical Formula: C9H13N3O4

Exact Mass: 227.0906

Molecular Weight: 227.22

Elemental Analysis: C, 47.57; H, 5.77; N, 18.49; O, 28.16

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250.00	2 Weeks
25g	USD 450.00	2 Weeks

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Related CAS #

3992-42-5 (HCl) 951-77-9 (free base)

Synonym

Doxecitine; Deoxycytidine; Desoxycytidin; Cytosine deoxyriboside; Deoxyribose cytidine;

IUPAC/Chemical Name

4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

InChi Key

CKTSBUTUHBMZGZ-SHYZEUOFSA-N

InChi Code

InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1

SMILES Code

O=C1N=C(N)C=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2

Appearance

Solid powder

Purity

>97% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	0.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 227.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kolganova NA, Vasiliskov VA, Kuznetsova VE, Shershov VE, Lapa SA, Guseinov TO, Spitsyn MA, Timofeev EN, Chudinov AV. Factors Affecting the Tailing of Blunt End DNA with Fluorescent Pyrimidine dNTPs. Mol Biotechnol. 2018 Sep 22. doi: 10.1007/s12033-018-0124-1. [Epub ahead of print] PubMed PMID: 30244435. 2: Yousef BA, Dirar AI, Elbadawi MAA, Awadalla MK, Mohamed MA. Potential Deoxycytidine Kinase Inhibitory Activity of Amaryllidaceae Alkaloids: An In Silico Approach. J Pharm Bioallied Sci. 2018 Jul-Sep;10(3):137-143. doi: 10.4103/jpbs.JPBS_44_18. PubMed PMID: 30237684; PubMed Central PMCID: PMC6142884. 3: Wu XL, Li R, Zhang HW, Jin R, Wang JY, Juan CX, Lu K, Shu J, Wang LL, Wang Y, Zhuang LL, Zhou GP. Methylation status of ORMDL3 regulates cytokine production and p-ERK/MMP9 pathway expression. Exp Cell Res. 2018 Sep 11. pii: S0014-4827(18)30539-1. doi: 10.1016/j.yexcr.2018.09.008. [Epub ahead of print] PubMed PMID: 30217493. 4: Gerecke C, Schumacher F, Edlich A, Wetzel A, Yealland G, Neubert LK, Scholtka B, Homann T, Kleuser B. Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells. Oncotarget. 2018 Aug 28;9(67):32822-32840. doi: 10.18632/oncotarget.25999. eCollection 2018 Aug 28. PubMed PMID: 30214687; PubMed Central PMCID: PMC6132357. 5: Mao J, Li S, Zhao H, Zhu Y, Hong M, Zhu H, Qian S, Li J. Effects of chidamide and its combination with decitabine on proliferation and apoptosis of leukemia cell lines. Am J Transl Res. 2018 Aug 15;10(8):2567-2578. eCollection 2018. PubMed PMID: 30210693; PubMed Central PMCID: PMC6129529. 6: Pisciotta A, Manteca A, Alduina R. The SCO1731 methyltransferase modulates actinorhodin production and morphological differentiation of Streptomyces coelicolor A3(2). Sci Rep. 2018 Sep 12;8(1):13686. doi: 10.1038/s41598-018-32027-8. PubMed PMID: 30209340; PubMed Central PMCID: PMC6135851. 7: Rogers RA, Fleming AM, Burrows CJ. Rapid Screen of Potential i-Motif Forming Sequences in DNA Repair Gene Promoters. ACS Omega. 2018 Aug 31;3(8):9630-9635. doi: 10.1021/acsomega.8b01551. Epub 2018 Aug 21. PubMed PMID: 30198001; PubMed Central PMCID: PMC6120732. 8: Fuss H, Lademann J, Jung S. Influence of Sorafenib, Sunitinib and Capecitabine on the Antioxidant Status of the Skin. Anticancer Res. 2018 Sep;38(9):5283-5288. doi: 10.21873/anticanres.12854. PubMed PMID: 30194179. 9: Guo C, Xie C, Chen Q, Cao X, Guo M, Zheng S, Wang Y. A novel malic acid-enhanced method for the analysis of 5-methyl-2'-deoxycytidine, 5-hydroxymethyl-2'-deoxycytidine, 5-methylcytidine and 5-hydroxymethylcytidine in human urine using hydrophilic interaction liquid chromatography-tandem mass spectrometry. Anal Chim Acta. 2018 Nov 30;1034:110-118. doi: 10.1016/j.aca.2018.06.081. Epub 2018 Jul 3. PubMed PMID: 30193624. 10: Barszcz M, Taciak M, Tuśnio A, Święch E, Bachanek I, Kowalczyk P, Borkowski A, Skomiał J. The effect of dietary level of two inulin types differing in chain length on biogenic amine concentration, oxidant-antioxidant balance and DNA repair in the colon of piglets. PLoS One. 2018 Sep 7;13(9):e0202799. doi: 10.1371/journal.pone.0202799. eCollection 2018. PubMed PMID: 30192784; PubMed Central PMCID: PMC6128538. 11: Hirao-Suzuki M, Takeda S, Kobayashi T, Kino K, Miyazawa H, Waalkes MP, Takiguchi M. Cadmium down-regulates apolipoprotein E (ApoE) expression during malignant transformation of rat liver cells: direct evidence for DNA hypermethylation in the promoter region of ApoE. J Toxicol Sci. 2018;43(9):537-543. doi: 10.2131/jts.43.537. PubMed PMID: 30185694. 12: Liu M, Thomas SL, DeWitt AK, Zhou W, Madaj ZB, Ohtani H, Baylin SB, Liang G, Jones PA. Dual inhibition of DNA and histone methyltransferases increases viral mimicry in ovarian cancer cells. Cancer Res. 2018 Sep 5. pii: canres.3953.2017. doi: 10.1158/0008-5472.CAN-17-3953. [Epub ahead of print] PubMed PMID: 30185548. 13: Florea ID, Karaoulani C. Epigenetic Changes of the Immune System with Role in Tumor Development. Methods Mol Biol. 2018;1856:203-218. doi: 10.1007/978-1-4939-8751-1_11. PubMed PMID: 30178253. 14: Fan B, Shen C, Wu M, Zhao J, Guo Q, Luo Y. miR-17-92 cluster is connected with disease progression and oxaliplatin/capecitabine chemotherapy efficacy in advanced gastric cancer patients: A preliminary study. Medicine (Baltimore). 2018 Aug;97(35):e12007. doi: 10.1097/MD.0000000000012007. PubMed PMID: 30170406. 15: Mehta AP, Wang Y, Reed SA, Supekova L, Javahishvili T, Chaput JC, Schultz PG. Bacterial Genome Containing Chimeric DNA-RNA Sequences. J Am Chem Soc. 2018 Sep 12;140(36):11464-11473. doi: 10.1021/jacs.8b07046. Epub 2018 Aug 30. PubMed PMID: 30160955. 16: Agrawal K, Das V, Táborská N, Gurský J, Džubák P, Hajdúch M. Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs. Stem Cells Int. 2018 Aug 12;2018:6013728. doi: 10.1155/2018/6013728. eCollection 2018. PubMed PMID: 30158986; PubMed Central PMCID: PMC6109465. 17: Belostotskii AM. Nanosecond-Scale Isomerization of the 4'-Carboxonium Cation Oxidatively Produced in Pyrimidine Units of DNA. J Org Chem. 2018 Sep 7. doi: 10.1021/acs.joc.8b01580. [Epub ahead of print] PubMed PMID: 30153025. 18: Zhang W, Bi Y, Wang Y, Wang M, Li D, Cheng S, Jin J, Li T, Li B, Zhang Y. Nanos2 promotes differentiation of male germ cells basing on the negative regulation of Foxd3 and the treatment of 5-Azadc and TSA. J Cell Physiol. 2018 Aug 26. doi: 10.1002/jcp.27139. [Epub ahead of print] PubMed PMID: 30146792. 19: Rechkoblit O, Choudhury JR, Buku A, Prakash L, Prakash S, Aggarwal AK. Structural basis for polymerase η-promoted resistance to the anticancer nucleoside analog cytarabine. Sci Rep. 2018 Aug 23;8(1):12702. doi: 10.1038/s41598-018-30796-w. PubMed PMID: 30140014; PubMed Central PMCID: PMC6107656. 20: Liu H, Yan Z, Yin Q, Cao K, Wei Y, Rodriguez-Canales J, Ma D, Wu Y. RUNX3 Epigenetic Inactivation Is Associated With Estrogen Receptor Positive Breast Cancer. J Histochem Cytochem. 2018 Aug 22:22155418797315. doi: 10.1369/0022155418797315. [Epub ahead of print] PubMed PMID: 30133331.