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MedKoo Cat#: 584553 | Name: Lotucaine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lotucaine is a local anesthetic.

Chemical Structure

Lotucaine
Lotucaine
CAS#52304-85-5 (free base)

Theoretical Analysis

MedKoo Cat#: 584553

Name: Lotucaine

CAS#: 52304-85-5 (free base)

Chemical Formula: C18H29NO2

Exact Mass: 291.2198

Molecular Weight: 291.44

Elemental Analysis: C, 74.18; H, 10.03; N, 4.81; O, 10.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
52304-85-5 (free base) 97467-70-4 (HCl)
Synonym
Lotucaine
IUPAC/Chemical Name
1-Pyrrolidineethanol, 2,2,5,5-tetramethyl-alpha-((2-methylphenoxy)methyl)
InChi Key
ALJMIOMYHUNJQX-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H29NO2/c1-14-8-6-7-9-16(14)21-13-15(20)12-19-17(2,3)10-11-18(19,4)5/h6-9,15,20H,10-13H2,1-5H3
SMILES Code
OC(COC1=CC=CC=C1C)CN2C(C)(C)CCC2(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 291.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Corral C, el-Ashmawy MB, Lissavetzky J, Bravo L, Darias V, Martin D. Synthesis and pharmacological evaluation of thiophene analogs of lotucaine. Farmaco Sci. 1987 Apr;42(4):267-75. PubMed PMID: 3595838. 2: Grippaudo G, Lolli R, Monaco B. [Experimental comparison of 2 anesthetics, carbocaine and lotucaine, in dentistry]. Dent Cadmos. 1985 Jun 30;53(11):93-6, 99-100. Italian. PubMed PMID: 3867522. 3: Ferrero E, Manzoni L, Dall'Asta L, Pedrazzoli A. Derivatives of tetramethylated cyclic amines. 3. Optical isomers of lotucaine: physico-chemical characteristics and pharmacological activities. Arzneimittelforschung. 1973 Nov;23(11):1596-8. PubMed PMID: 4801667.

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