Synonym
NSC368262; NSC-368262; NSC 368262; C48; C-48; C 48
IUPAC/Chemical Name
6-[(2-Pyridinylamino)(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol
InChi Key
LAMGRAMZRMRRMH-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H22N2O6/c1-26-18-8-13(9-19(27-2)22(18)28-3)21(24-20-6-4-5-7-23-20)14-10-16-17(11-15(14)25)30-12-29-16/h4-11,21,25H,12H2,1-3H3,(H,23,24)
SMILES Code
OC1=C(C(NC2=NC=CC=C2)C3=CC(OC)=C(OC)C(OC)=C3)C=C(OCO4)C4=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
410.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Buettner R, Corzano R, Rashid R, Lin J, Senthil M, Hedvat M, Schroeder A, Mao A, Herrmann A, Yim J, Li H, Yuan YC, Yakushijin K, Yakushijin F, Vaidehi N, Moore R, Gugiu G, Lee TD, Yip R, Chen Y, Jove R, Horne D, Williams JC. Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development. ACS Chem Biol. 2011 May 20;6(5):432-43. doi: 10.1021/cb100253e. Epub 2011 Feb 16. PubMed PMID: 21226522; PubMed Central PMCID: PMC3098940.
