PSB-1737 | CAS#139896-80-3

MedKoo Cat#: 555311 | Name: PSB-1737

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PSB-1737 is a Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17 (EC50 270 nM).

Chemical Structure

PSB-1737

CAS#139896-80-3

Theoretical Analysis

MedKoo Cat#: 555311

Name: PSB-1737

CAS#: 139896-80-3

Chemical Formula: C18H15NO5

Exact Mass: 325.0950

Molecular Weight: 325.32

Elemental Analysis: C, 66.46; H, 4.65; N, 4.31; O, 24.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PSB-1737; PSB 1737; PSB1737;

IUPAC/Chemical Name

3-(2-Carboxyethyl)-6-phenoxy-1H-indole-2-carboxylic acid

InChi Key

PKFAYNLUAGDMNZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H15NO5/c20-16(21)9-8-14-13-7-6-12(24-11-4-2-1-3-5-11)10-15(13)19-17(14)18(22)23/h1-7,10,19H,8-9H2,(H,20,21)(H,22,23)

SMILES Code

O=C(C(N1)=C(CCC(O)=O)C2=C1C=C(OC3=CC=CC=C3)C=C2)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

The orphan receptor GPR17 may be a novel drug target for inflammatory diseases. GPR17 antagonists have potential for the treatment of demyelinating diseases such as multiple sclerosis based on the observation that GPR17 knockout mice showed increased myelination.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 325.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Baqi Y, Pillaiyar T, Abdelrahman A, Kaufmann O, Alshaibani S, Rafehi M, Ghasimi S, Akkari R, Ritter K, Simon K, Spinrath A, Kostenis E, Zhao Q, Köse M, Namasivayam V, Müller CE. 3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17. J Med Chem. 2018 Sep 5. doi: 10.1021/acs.jmedchem.7b01768. [Epub ahead of print] PubMed PMID: 30048589.