Synonym
BE 2254; BE-2254; BE2254
IUPAC/Chemical Name
1(2H)-Naphthalenone, 3,4-dihydro-2-(((2-(4-hydroxyphenyl)ethyl)amino)methyl)-
InChi Key
PZZOEXPDTYIBPI-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21NO2/c21-17-9-5-14(6-10-17)11-12-20-13-16-8-7-15-3-1-2-4-18(15)19(16)22/h1-6,9-10,16,20-21H,7-8,11-13H2
SMILES Code
O=C1C(CNCCC2=CC=C(O)C=C2)CCC3=C1C=CC=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
295.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Szreder Z. The effect of BE 2254 on the metabolic response stimulated by pyrogen in rabbits. Gen Pharmacol. 1993 Jan;24(1):177-83. PubMed PMID: 8097739.
2: Adams A, Jarrott B. Thermodynamics of agonist and antagonist binding to the alpha 1-adrenoceptor studied using [125I]BE 2254. Biochem Biophys Res Commun. 1985 Apr 30;128(2):816-23. PubMed PMID: 2986627.
3: Adams A, Jarrott B. Deafferentation of the rat hippocampus does not alter the affinity or binding capacity for the alpha 1-adrenoceptor radioligand [125I]BE 2254. Neurosci Lett. 1984 Dec 21;52(3):311-6. PubMed PMID: 6097843.
4: Schlicker E, Brodde OE, Göthert M, Schaperdoth M. Increased affinity and preference of halogenated derivatives of BE 2254 for alpha 1-adrenoceptors demonstrated by functional and binding experiments. J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1238-44. PubMed PMID: 6084785.
5: Göthert M, Dieckhöfer C, Nolte J. Preferential blockade of alpha 1-adrenoceptors in the rabbit pulmonary artery by derivatives of beta-phenylethylamine chemically related to BE 2254 (heat). J Cardiovasc Pharmacol. 1983 Jan-Feb;5(1):12-8. PubMed PMID: 6186846.
6: Engel G, Hoyer D. [125Iodo]BE 2254, a new radioligand for alpha 1-adrenoceptors. J Cardiovasc Pharmacol. 1982;4 Suppl 1:S25-9. PubMed PMID: 6175839.
7: Hicks PE. Antagonism of pre and postsynaptic alpha-adrenoreceptors by BE 2254 (HEAT) and prazosin. J Auton Pharmacol. 1981 Dec;1(5):391-7. PubMed PMID: 6123512.
8: Engel G, Hoyer D. [125I]BE 2254, a new high affinity radioligand for alpha 1-adrenoceptors. Eur J Pharmacol. 1981 Jul 17;73(2-3):221-4. PubMed PMID: 6273186.
9: Göthert M, Nolte J, Weinheimer G. Preferential blockade of postsynaptic alpha-adrenoceptors by BE 2254. Eur J Pharmacol. 1981 Mar 5;70(1):35-42. PubMed PMID: 6111463.
10: Heinz N, Hofferber E. [On the pharmacology of the alpha-receptor blocker BE 2254 (HEAT) (author's transl)]. Arzneimittelforschung. 1980;30(12):2135-9. German. PubMed PMID: 6111325.
11: Clineschmidt BV, Pflueger AB, Bunting PR, McGuffin JC, Ballentine RJ. Central catecholamine receptor blocking actions of BE-2254 ('heat'): comparison with chlorpromazine and haloperidol. Eur J Pharmacol. 1975 Jun-Jul;32(02):279-86. PubMed PMID: 1171016.
