ELN 582175 | CAS#unknown | PLK2 inhibitor

MedKoo Cat#: 463906 | Name: ELN 582175

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ELN 582175 is a PLK2 inhibitor.

Chemical Structure

ELN 582175

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463906

Name: ELN 582175

CAS#: unknown

Chemical Formula: C21H22N6O2

Exact Mass: 390.1804

Molecular Weight: 390.45

Elemental Analysis: C, 64.60; H, 5.68; N, 21.52; O, 8.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ELN 582175; ELN582175; ELN-582175;

IUPAC/Chemical Name

(S)-6a-ethyl-5-methyl-2-(2-phenyl-1H-imidazol-1-yl)-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-6(5H)-one

InChi Key

UZBZLIAKCDCTBS-NRFANRHFSA-N

InChi Code

InChI=1S/C21H22N6O2/c1-3-21-14-29-12-11-27(21)18-16(25(2)19(21)28)13-23-20(24-18)26-10-9-22-17(26)15-7-5-4-6-8-15/h4-10,13H,3,11-12,14H2,1-2H3/t21-/m0/s1

SMILES Code

CN(C1=CN=C(N2C(C3=CC=CC=C3)=NC=C2)N=C1N4[C@@]5(CC)COCC4)C5=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 390.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fitzgerald K, Bergeron M, Willits C, Bowers S, Aubele DL, Goldbach E, Tonn G, Ness D, Olaharski A. Pharmacological inhibition of polo like kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei. Toxicol Appl Pharmacol. 2013 May 15;269(1):1-7. doi: 10.1016/j.taap.2013.02.012. Epub 2013 Mar 1. PMID: 23466428.