NCGC00379308 | D3-ßArr | CAS# 662164-09-2 | TSH receptor PAM

MedKoo Cat#: 563811 | Name: NCGC00379308

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NCGC00379308, also known as D3-ßArr, is a Positive Allosteric Modulator (PAM) of the TSH receptor. D3-ßArr potentiates the effect of TSH in stimulating β-Arr 1 translocation.

Chemical Structure

NCGC00379308

CAS#662164-09-2

Theoretical Analysis

MedKoo Cat#: 563811

Name: NCGC00379308

CAS#: 662164-09-2

Chemical Formula: C20H23N5

Exact Mass: 333.1953

Molecular Weight: 333.44

Elemental Analysis: C, 72.04; H, 6.95; N, 21.00

Price and Availability

Size	Price	Availability	Quantity
1g	USD 3,850.00
2g	USD 7,450.00

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

D3-ßArr; D3ßArr; D3 ßArr; NCGC00379308; NCGC-00379308; NCGC 00379308;

IUPAC/Chemical Name

N-(1-Phenylethyl)-2-(1-piperazinyl)-4-quinazolinamine

InChi Key

LOGWGZNWEWFTJV-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H23N5/c1-15(16-7-3-2-4-8-16)22-19-17-9-5-6-10-18(17)23-20(24-19)25-13-11-21-12-14-25/h2-10,15,21H,11-14H2,1H3,(H,22,23,24)

SMILES Code

CC(NC1=C2C=CC=CC2=NC(N3CCNCC3)=N1)C4=CC=CC=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

NCGC00379308, also known as D3-ßArr, is a Positive Allosteric Modulator (PAM) of the TSH receptor.

In vitro activity:

In DiscoverX1 cells, D3-βArr stimulated β-Arr 1 translocation with a 5.1-fold greater efficacy than TSH and therefore potentiated the effect of TSH in stimulating β-Arr 1 translocation. D3-βArr alone had only a weak effect to upregulate these bone markers, but D3-βArr potentiated TSH-induced upregulation of ALPL and OPN mRNA levels 1.6-fold and 5.5-fold, respectively, at the maximum dose of ligands. Furthermore, the positive allosteric modulator effect of D3-βArr resulted in an increase of TSH-induced secretion of OPN protein. Reference: J Pharmacol Exp Ther. 2018 Jan;364(1):38-45. https://pubmed.ncbi.nlm.nih.gov/29089368/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	81.0	242.92
	Ethanol	33.0	98.97

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 333.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Neumann S, Eliseeva E, Boutin A, Barnaeva E, Ferrer M, Southall N, Kim D, Hu X, Morgan SJ, Marugan JJ, Gershengorn MC. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45. doi: 10.1124/jpet.117.244095. Epub 2017 Oct 31. PMID: 29089368; PMCID: PMC5729612.

In vitro protocol:

In vivo protocol:

TBD