5-Methyltryptamine hydrochloride | CAS#1010-95-3 | 5-HT receptor agonist

MedKoo Cat#: 561660 | Name: 5-Methyltryptamine hydrochloride

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

5-Methyltryptamine hydrochloride acts as a 5-HT receptor agonist.

Chemical Structure

5-Methyltryptamine hydrochloride

CAS#1010-95-3

Theoretical Analysis

MedKoo Cat#: 561660

Name: 5-Methyltryptamine hydrochloride

CAS#: 1010-95-3

Chemical Formula: C11H15ClN2

Exact Mass: 210.0924

Molecular Weight: 210.70

Elemental Analysis: C, 62.70; H, 7.18; Cl, 16.82; N, 13.30

Price and Availability

Size	Price	Availability
1g	USD 450.00	2 Weeks
2g	USD 750.00	2 Weeks
5g	USD 1,450.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

5-Methyltryptamine hydrochloride;

IUPAC/Chemical Name

2-(5-Methyl-1H-indol-3-yl)ethanamine hydrochloride

InChi Key

RBHDFGBPJGEYCK-UHFFFAOYSA-N

InChi Code

InChI=1S/C11H14N2.ClH/c1-8-2-3-11-10(6-8)9(4-5-12)7-13-11;/h2-3,6-7,13H,4-5,12H2,1H3;1H

SMILES Code

CC1=CC2=C(NC=C2CCN)C=C1.[H]Cl

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 210.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bower KS, Price KL, Sturdee LE, Dayrell M, Dougherty DA, Lummis SC. 5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function. Eur J Pharmacol. 2008 Feb 12;580(3):291-7. Epub 2007 Nov 17. PubMed PMID: 18082160; PubMed Central PMCID: PMC2649378. 2: Sirikatitham A, Yamamoto T, Shimizu M, Hasegawa T, Tsuyama N, Masujima T. Resin-packed nanoelectrospray in combination with video and mass spectrometry for the direct and real-time molecular analysis of mast cells. Rapid Commun Mass Spectrom. 2007;21(3):385-90. PubMed PMID: 17206747. 3: Kloda A, Adams DJ. Voltage-dependent inhibition of recombinant NMDA receptor-mediated currents by 5-hydroxytryptamine. Br J Pharmacol. 2005 Feb;144(3):323-30. PubMed PMID: 15655527; PubMed Central PMCID: PMC1576009. 4: Sallés J, López de Jesús M, Goñi O, Fernández-Teruel A, Driscoll P, Tobeña A, Escorihuela RM. Transmembrane signaling through phospholipase C in cortical and hippocampal membranes of psychogenetically selected rat lines. Psychopharmacology (Berl). 2001 Mar 1;154(2):115-25. PubMed PMID: 11314673. 5: Garro MA, López de Jesús M, Ruíz de Azúa I, Callado LF, Meana JJ, Sallés J. Regulation of phospholipase Cbeta activity by muscarinic acetylcholine and 5-HT(2) receptors in crude and synaptosomal membranes from human cerebral cortex. Neuropharmacology. 2001 Apr;40(5):686-95. PubMed PMID: 11311896. 6: Berger ML. Tryptamine derivatives as non-competitive N-methyl-D-aspartate receptor blockers: studies using [(3)H]MK-801 binding in rat hippocampal membranes. Neurosci Lett. 2000 Dec 15;296(1):29-32. PubMed PMID: 11099826. 7: Uchiyama-Tsuyuki Y, Saitoh M, Muramatsu M. Identification and characterization of the 5-HT4 receptor in the intestinal tract and striatum of the guinea pig. Life Sci. 1996;59(25-26):2129-37. PubMed PMID: 8950316. 8: Tolloczko B, Jia YL, Martin JG. Serotonin-evoked calcium transients in airway smooth muscle cells. Am J Physiol. 1995 Aug;269(2 Pt 1):L234-40. PubMed PMID: 7653586. 9: Watts SW, Cohen ML, Mooney PQ, Johnson BG, Schoepp DD, Baez M. Disruption of potential alpha-helix in the G loop of the guinea pig 5-hydroxytryptamine2 receptor does not prevent receptor coupling to phosphoinositide hydrolysis. J Neurochem. 1994 Mar;62(3):934-43. PubMed PMID: 8113814. 10: Cushing DJ, Baez M, Kursar JD, Schenck K, Cohen ML. Serotonin-induced contraction in canine coronary artery and saphenous vein: role of a 5-HT1D-like receptor. Life Sci. 1994;54(22):1671-80. PubMed PMID: 7909909. 11: Sallés J, Wallace MA, Fain JN. Modulation of the phospholipase C activity in rat brain cortical membranes by simultaneous activation of distinct monoaminergic and cholinergic muscarinic receptors. Brain Res Mol Brain Res. 1993 Oct;20(1-2):111-7. PubMed PMID: 8255172. 12: Yang DC, Goldstin B, Moormann AE, Flynn DL, Gullikson GW. SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae. J Pharmacol Exp Ther. 1993 Sep;266(3):1339-47. PubMed PMID: 8396633. 13: Watts SW, Cohen ML. Further evidence that the guinea pig tracheal contractile serotonergic receptor is a 5-hydroxytryptamine2 receptor: use of 5-methyltryptamine and dipropyl-5-carboxamidotryptamine. J Pharmacol Exp Ther. 1993 Jan;264(1):271-5. PubMed PMID: 8423530. 14: Kojima S, Ishizaki R, Shimo Y. Investigation into the 5-hydroxytryptamine-induced relaxation of the circular smooth muscle of guinea-pig stomach fundus. Eur J Pharmacol. 1992 Nov 24;224(1):45-9. PubMed PMID: 1451742. 15: Cushing DJ, Cohen ML. Serotonin-induced relaxation in canine coronary artery smooth muscle. J Pharmacol Exp Ther. 1992 Oct;263(1):123-9. PubMed PMID: 1403777. 16: Borden KL, Beckmann P, Lane AN. Determination of the orientations of tryptophan analogues bound to the trp repressor and the relationship to activation. Eur J Biochem. 1991 Dec 5;202(2):459-70. PubMed PMID: 1761046. 17: Ben-Harari RR, Dalton BA, Osman R, Maayani S. Kinetic characterization of 5-hydroxytryptamine receptor desensitization in isolated guinea-pig trachea and rabbit aorta. J Pharmacol Exp Ther. 1991 Apr;257(1):416-24. PubMed PMID: 1850475. 18: Wallace MA, Claro E. Comparison of serotoninergic to muscarinic cholinergic stimulation of phosphoinositide-specific phospholipase C in rat brain cortical membranes. J Pharmacol Exp Ther. 1990 Dec;255(3):1296-300. PubMed PMID: 2175801. 19: Soblosky JS, Dills C, DuMontier G, Jeng I. Evidence for 5-HT1A binding sites in chick embryo brain and discrimination by 5-methoxytryptamine. Biochem Int. 1987 May;14(5):797-803. PubMed PMID: 2970262. 20: Zychlinski L, Montgomery MR. Species differences in lung mitochondrial monoamine oxidase activities. Comp Biochem Physiol C. 1987;86(2):325-8. PubMed PMID: 2882925.